Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis in Head and Neck Cancer: A Systematic Review and Meta-Analysis
Kyoungjune Pak,Kyoungjune Pak,Gi Jeong Cheon,Hyun Nam,Seong Jang Kim,Keon Wook Kang,June-Key Chung,E. Edmund Kim,E. Edmund Kim,Dong Soo Lee,Dong Soo Lee +10 more
TLDR
Despite clinically heterogeneous HNC and the various methods adopted between studies, it can confirm that patients with a high MTV or TLG have a higher risk of adverse events or death.Abstract:
We conducted a comprehensive systematic review of the literature on volumetric parameters and a meta-analysis of the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with head and neck cancer (HNC). Methods: A systematic search of MEDLINE and EMBASE was performed using the key words PET, head and neck, and volume. Inclusion criteria were 18 F-FDG PET used as an initial imaging tool; studies limited to HNC; patients who had not undergone surgery, chemotherapy, or radiotherapy before PET scans; and studies reporting survival data. Event-free survival and overall survival were considered markers of outcome. The impact of MTV or TLG on survival was measured by the effect size hazard ratio (HR). Data from each study were analyzed using Review Manager. Results: Thirteen studies comprising 1,180 patients were included in this study. The combined HR for adverse events was 3.06 (2.33–4.01, P , 0.00001) with MTV and 3.10 (2.27–4.24, P , 0.00001) with TLG, meaning that tumors with high volumetric parameters were associated with progression or recurrence. Regarding overall survival, the pooled HR was 3.51 (2.62–4.72, P , 0.00001) with MTV and 3.14 (2.24–4.40, P , 0.00001) with TLG. There was no evidence of significant statistical heterogeneity at an I2 of 0%. Conclusion: MTV and TLG are prognostic predictors of outcome in patients with HNC. Despite clinically heterogeneous HNC and the various methods adopted between studies, we can confirm that patients with a high MTV or TLG have a higher risk of adverse events or death.read more
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Prognostic value of volumetric parameters of (18)F-FDG PET in non-small-cell lung cancer: a meta-analysis.
Hyung Jun Im,Kyoungjune Pak,Kyoungjune Pak,Gi Jeong Cheon,Keon Wook Kang,Seong Jang Kim,In Joo Kim,June-Key Chung,E. Edmund Kim,Dong Soo Lee +9 more
TL;DR: Volumetric parameters from 18F-FDG PET are significant prognostic factors for outcome in patients with NSCLC and patients with a high MTV or TLG are at higher risk of adverse events and death.
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Current Methods to Define Metabolic Tumor Volume in Positron Emission Tomography: Which One is Better?
TL;DR: This review discusses currently available methods to measure MTV using FDG PET, and assess the advantages and disadvantages of the methods.
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Gluconeogenesis in cancer cells - Repurposing of a starvation-induced metabolic pathway?
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References
More filters
Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints.
TL;DR: A number of methods of extracting estimates of the log hazard ratio and its variance in a variety of situations are presented to improve the efficiency and reliability of meta-analyses of the published literature with survival-type endpoints.
Journal ArticleDOI
Dangers of using "optimal" cutpoints in the evaluation of prognostic factors.
Journal ArticleDOI
Primary Tumor Standardized Uptake Value (SUVmax) Measured on Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is of Prognostic Value for Survival in Non-small Cell Lung Cancer (NSCLC): A Systematic Review and Meta-Analysis (MA) by the European Lung Cancer Working Party for the IASLC Lung Cancer Staging Project
Thierry Berghmans,Michèle Dusart,Marianne Paesmans,Claude Hossein-Foucher,Irène Buvat,Catherine Castaigne,Arnaud Scherpereel,Céline Mascaux,Michel Moreau,Martine Roelandts,Stéphane Alard,Anne-Pascale Meert,Edward F. Patz,Jean-Jacques Lafitte,Jean-Paul Sculier +14 more
TL;DR: In this article, the authors conducted a systematic literature search and found 13 eligible studies dedicated to non-small cell lung cancer (NSCLC) and found that the primary tumor standardized uptake value (SUV) has a potential prognostic factor for survival.