Journal ArticleDOI
Prolonged circulation time of doxorubicin-loaded liposomes coated with a modified polyvinyl alcohol after intravenous injection in rats.
Hirofumi Takeuchi,Hiroyuki Kojima,Toshitada Toyoda,Hiromitsu Yamamoto,Tomoaki Hino,Yoshiaki Kawashima +5 more
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TLDR
Results confirm that polymer possessing a hydrophobic anchor at its end, like PVA-R, is a suitable material for modifying the surface of doxorubicin-loaded liposomes to improve their stability in the circulating blood.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 1999-09-01. It has received 69 citations till now. The article focuses on the topics: Drug carrier & Liposome.read more
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Journal ArticleDOI
Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor.
Eun Seong Lee,Kun Na,You Han Bae +2 more
TL;DR: The results demonstrate that PHSM/f is a viable means for treating drug resistant tumors and may endow the drug carriers to bypass Pgp efflux pump and sequestration of DOX in acidic intracellular compartments, yielding high cytotyoxicity.
Journal ArticleDOI
Multifunctional and stimuli-sensitive pharmaceutical nanocarriers.
TL;DR: This paper considers the current status and possible future directions in the emerging area of multifunctional nanocarriers with primary attention on the combination of such properties as longevity, targetability, intracellular penetration, contrast loading, and stimuli-sensitivity.
Book ChapterDOI
Passive and active drug targeting: drug delivery to tumors as an example.
TL;DR: Among various approaches to specifically target drug-loaded carrier systems to required pathological sites in the body, two seem to be most advanced--passive (EPR effect-mediated) targeting and active targeting, based on the attachment of specific ligands to the surface of pharmaceutical carriers to recognize and bind pathological cells.
Journal ArticleDOI
Liposomes as carriers of hydrophilic small molecule drugs: strategies to enhance encapsulation and delivery.
Josimar O. Eloy,Josimar O. Eloy,Marina Claro de Souza,Raquel Petrilli,Juliana Palma Abriata Barcellos,Robert J. Lee,Juliana Maldonado Marchetti +6 more
TL;DR: The rapidly increasing knowledge of the many overexpressed biochemical makers in pathological sites has enabled the development of liposomes decorated with ligands for cell-surface receptors and active delivery, resulting in an optimal therapeutic effect devoid of side effects.
Journal ArticleDOI
Targeted delivery of doxorubicin using stealth liposomes modified with transferrin.
TL;DR: The study indicated that the Tf-coupled PEG liposomes (Tf-SL) could be as the targeted carriers to facilitate the delivery of the encapsulated anticancer drugs into tumor cells by receptor-mediated way.
References
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Journal ArticleDOI
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.
Demetrios Papahadjopoulos,Theresa M. Allen,Alberto Gabizon,E Mayhew,Katherine K. Matthay,Shi Kun Huang,Karim Lee,M C Woodle,D D Lasic,C Redemann +9 more
TL;DR: Liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs and have expanded considerably the prospects of liposomes as an effective carrier system for a variety of pharmacologically active macromolecules.
Journal ArticleDOI
Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
TL;DR: A carbamate derivative of PEG-1900 with distearoylphosphatidylethanolamine (PEG-DSPE) had the greatest ability to decrease MPS uptake of liposomes, at optimum concentrations of 5-7 mol% in liposome composed of sphingomyelin/egg phosphatidylcholine/cholesterol (SM/PC/Chol, 1:1:1, molar ratio).
Journal ArticleDOI
Sterically stabilized liposomes
Martin C. Woodle,Danilo D. Lasic +1 more
TL;DR: The structure-function relationship of PEG-derivatized phosphatidylethanolamine (PEG-PE) has been examined by measurement of blood lifetime and tissue distribution in both mice and rats and Steric stabilization has been proposed as a theoretical basis for the results.
Journal ArticleDOI
Large unilamellar liposomes with low uptake into the reticuloendothelial system
Theresa M. Allen,A. Chonn +1 more
TL;DR: The significantly extended circulation times achieved by these modified large unilamellar liposomes overcome an important barrier to the targeting of particulate drug carriers to specific tissues in vivo.
Journal Article
Fate and behavior of liposomes in vivo: a review of controlling factors.
TL;DR: Results of recent studies are brought together which describe how liposomal stability and clearance in vivo are controlled by the architecture of the vesicles themselves which in turn, via interaction with humoral factors, controls the fate in terms of tissue distribution of the carrier and its contents.
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A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more