Propranolol 0.2% Eye Micro-Drops for Retinopathy of Prematurity: A Prospective Phase IIB Study.
Luca Filippi,Giacomo Cavallaro,Giacomo Cavallaro,Elettra Berti,Letizia Padrini,Gabriella Araimo,Giulia Regiroli,Giulia Regiroli,Genny Raffaeli,Genny Raffaeli,Valentina Bozzetti,Paolo Tagliabue,Barbara Tomasini,Annalisa Mori,Giuseppe Buonocore,Massimo Agosti,Angela Bossi,Gaetano Chirico,Salvatore Aversa,Pina Fortunato,Silvia Osnaghi,Barbara Cavallotti,Martina Suzani,Maurizio Vanni,Giulia Borsari,Simone Donati,Giuseppe Nascimbeni,Daniel Nardo,Stefano Piermarocchi,Giancarlo la Marca,Giulia Forni,Silvano Milani,Ivan Cortinovis,Maura Calvani,Paola Bagnoli,Massimo Dal Monte,Anna Maria Calvani,Alessandra Pugi,Eduardo Villamor,Gianpaolo Donzelli,Fabio Mosca,Fabio Mosca +41 more
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TLDR
Propranolol administered too early appears to favor a more aggressive ROP, suggesting that a β-adrenoreceptor blockade is only useful during the proliferative phase.Abstract:
Background. Oral propranolol reduces retinopathy of prematurity (ROP) progression, although not safely. Propranolol 0.1% eye micro-drops administered to newborns with stage 2 ROP are well tolerated, but not sufficiently effective. Methods. A multicenter open-label trial was conducted to assess safety and efficacy of propranolol 0.2% eye micro-drops in newborns with stage 1 ROP. The progression of the disease was evaluated with serial ophthalmologic examinations. Hemodynamic, respiratory, biochemical parameters and propranolol plasma levels were monitored. Results. Ninety-eight newborns were enrolled. The progression to ROP stage 2 or 3 plus was significantly lower than the incidence expected on the basis of historical data (Risk Ratio 0.521, 95% CI 0.297-0.916). No adverse effects related to propranolol were observed and the mean propranolol plasma level was significantly lower than the safety cut-off of 20 ng/mL. Unexpectedly, three newborns treated with oral propranolol before the appearance of ROP, showed a ROP unresponsive to propranolol eye micro-drops and required laser photocoagulation treatment. Conclusion. Propranolol 0.2% eye micro-drops reduced ROP progression and were well tolerated. Propranolol administered too early appears to favor a more aggressive ROP, suggesting that β-adrenoreceptor blockade is useful only during the proliferative phase. Further randomised placebo-controlled trials are required to confirm current results.read more
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The International Classification of Retinopathy of Prematurity Revisited : An International Committee for the Classification of Retinopathy of Prematurity
Glen A. Gole,Anna L. Ells,Ximena Katz,Gerd Holmström,Alistair R. Fielder,Antonio Capone,John T. Flynn,William G. Good,Jonathan M. Holmes,J. Arch McNamara,Earl A. Palmer,Graham E. Quinn,Michael J. Shapiro,Michael G. J. Trese,David K. Wallace +14 more
TL;DR: An international group of pediatric ophthalmologists and retinal specialists has developed a consensus document that revises some aspects of ICROP, including introduction of the concept of a more virulent form of retinopathy observed in the tiniest babies.
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The international classification of retinopathy of prematurity revisited
Glen A. Gole,Anna L. Ells,Ximena Katz,Gerd Holmström,Alistair R. Fielder,Antonio Capone,John T. Flynn,W. G. Good,Jonathan M. Holmes,J. A. McNamara,Earl A. Palmer,Graham E. Quinn,Michael J. Shapiro,Michael G. J. Trese,David K. Wallace +14 more
TL;DR: The International Classification of Retinopathy of Prematurity (ICROP) was published in 2 parts, the first in 1984 and later expanded in 1987 as discussed by the authors, which was a consensus statement of an international group of retinopathy experts.
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Oxygen-induced retinopathy in the mouse
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TL;DR: The authors have described a reproducible and quantifiable mouse model of oxygen-induced retinal neovascularization that should prove useful for the study of pathogenesis and therapeutic intervention for retinal nvascularization in retinopathy of prematurity (ROP) and other vasculopathologies.