Protein Kinase CK2α′ Is Induced by Serum as a Delayed Early Gene and Cooperates with Ha-ras in Fibroblast Transformation
Maurizio Orlandini,Francesca Semplici,Rebecca Ferruzzi,Flavio Meggio,Lorenzo A. Pinna,Salvatore Oliviero +5 more
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TLDR
The identification, cloning, and oncogenic activity of the murine CK2α′ subunit is reported, suggesting that unbalanced expression of a CK2 catalytic subunit synergizes with Ha-ras in cell transformation.About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-08-14 and is currently open access. It has received 119 citations till now. The article focuses on the topics: Cyclin-dependent kinase 2 & Casein kinase 2.read more
Citations
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Protein kinase CK2: structure, regulation and role in cellular decisions of life and death.
TL;DR: A mechanistic basis of the observation that CK2 is essential for viability may reside in part in this ability to protect cellular proteins from caspase action, which may contribute to its ability to participate in transformation and tumorigenesis.
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The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus IMPLICATIONS FOR PTEN STABILITY TO PROTEASOME-MEDIATED DEGRADATION
Josema Torres,Rafael Pulido +1 more
TL;DR: The results support the notion that proper phosphorylation of PTEN by CK2 is important for PTEN protein stability to proteasome-mediated degradation.
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Protein kinase CK2 and its role in cellular proliferation, development and pathology.
TL;DR: The structure of the catalytic subunit with the fixed positioning of the activation segment in the active conformation through its own aminoterminal region suggests a regulation at the transcriptional level making a regulation by second messengers unlikely.
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Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').
Stefania Sarno,Helen Reddy,Flavio Meggio,Maria Ruzzene,Stephen P. Davies,Arianna Donella-Deana,David Shugar,Lorenzo A. Pinna +7 more
TL;DR: Data show that TBB is a quite selective inhibitor of CK2, that can be used in cell‐based assays and also inhibits endogenous CK2 in cultured Jurkat cells.
Journal ArticleDOI
Protein kinase CK2 in mammary gland tumorigenesis.
Esther Landesman-Bollag,Raphaëlle Romieu-Mourez,Diane H. Song,Gail E. Sonenshein,Robert D. Cardiff,David C. Seldin,David C. Seldin +6 more
TL;DR: In mice, rats, and humans, dysregulated expression of CK2 is associated with and is capable of contributing to mammary tumorigenesis, and targeted inhibition of CK1 could be useful in the treatment of breast cancer.
References
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction
Peng Liang,Arthur B. Pardee +1 more
TL;DR: A method to separate and clone individual messenger RNAs (mRNAs) by means of the polymerase chain reaction using a set of oligonucleotide primers, one being anchored to the polyadenylate tail of a subset of mRNAs, the other being short and arbitrary in sequence so that it anneals at different positions relative to the first primer.
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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
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Cell-Specific Regulation of the c-myc Gene by Lymphocyte Mitogens and Platelet-Derived Growth Factor
TL;DR: A regulatory linkage between the function of two oncogenes--c-myc and c-sis--the latter being the putative structural gene for PDGF is suggested, consistent with a model that a labile protein may regulate c- myc levels in these cells.
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Induction of c- fos gene and protein by growth factors precedes activation of c- myc
TL;DR: Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction of expression of both c-fos mRNA and protein within a few minutes, followed by activation of c-myc.
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