Journal ArticleDOI
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
Alessandra Castegna,Michael Y. Aksenov,Marina V. Aksenova,Visith Thongboonkerd,Jon B. Klein,William M. Pierce,Rosemarie M. Booze,William R. Markesbery,D. Allan Butterfield +8 more
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TLDR
The powerful techniques, emerging from application of proteomics to neurodegenerative disease, reveal the presence of specific targets of protein oxidation in Alzheimer's disease (AD) brain: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2002-08-15. It has received 575 citations till now. The article focuses on the topics: Protein oxidation & Neurodegeneration.read more
Citations
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Journal ArticleDOI
Protein carbonyl groups as biomarkers of oxidative stress.
TL;DR: The usage of protein CO groups as biomarkers of oxidative stress has some advantages in comparison with the measurement of other oxidation products because of the relative early formation and the relative stability of carbonylated proteins.
Journal ArticleDOI
Clinical Diagnosis of Alzheimer's Disease
TL;DR: There are a number of ways in which a clinical diagnosis of dementia of the Alzheimer type can be made – the application of clinical criteria is the commonest but ancillary techniques such as neuroima are also used.
Journal ArticleDOI
Mitochondrial abnormalities in Alzheimer's disease.
Keisuke Hirai,Gjumrakch Aliev,Akihiko Nunomura,Akihiko Nunomura,Hisashi Fujioka,Robert L. Russell,Craig S. Atwood,Anne B. Johnson,Yvonne Kress,Harry V. Vinters,Massimo Tabaton,Shun Shimohama,Adam D. Cash,Sandra L. Siedlak,Peggy L.R. Harris,Paul K. Jones,Robert B. Petersen,George Perry,Mark A. Smith +18 more
TL;DR: Morphometric analysis showed that mitochondria are significantly reduced in Alzheimer's disease, and the relationship shown here between the site and extent of mitochondrial abnormalities and oxidative damage suggests an intimate and early association between these features in dementia.
Journal ArticleDOI
Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress.
TL;DR: This review summarizes current knowledge on phospholipid peroxidation and protein oxidation in AD brain, one potential cause of this oxidative stress, and consequences of A(beta)-induced lipid per oxidation andprotein oxidation inAD brain.
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Protein carbonylation in human diseases.
TL;DR: Rapid recent progress in the identification of carbonylated proteins should provide new diagnostic (possibly pre-symptomatic) biomarkers for oxidative damage, and yield basic information to aid the establishment an efficacious antioxidant therapy.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
The Ubiquitin System
Avram Hershko,Aaron Ciechanover +1 more
TL;DR: This review discusses recent information on functions and mechanisms of the ubiquitin system and focuses on what the authors know, and would like to know, about the mode of action of ubi...
Journal ArticleDOI
Protein Oxidation in Aging, Disease, and Oxidative Stress
Book ChapterDOI
Carbonyl assays for determination of oxidatively modified proteins
TL;DR: New methods for determination ofcarbonyl content are presented, which are based on the reaction of carbonyl groups with 2,4-dinitrophenylhydrazine to form a 2, 4-d Initrophenolhydrazone, which provide substantial improvements in both sensitivity and specificity.
Journal ArticleDOI
Oxidative stress hypothesis in alzheimer's disease
TL;DR: Supporting indirect evidence comes from a variety of in vitro studies showing that free radicals are capable of mediating neuron degeneration and death, suggesting that therapeutic efforts aimed at removal of ROS or prevention of their formation may be beneficial in AD.