Psoas muscle area is not representative of total skeletal muscle area in the assessment of sarcopenia in ovarian cancer.
Iris J. G. Rutten,Iris J. G. Rutten,Jorne Ubachs,Roy F.P.M. Kruitwagen,Roy F.P.M. Kruitwagen,Regina G. H. Beets-Tan,Regina G. H. Beets-Tan,Regina G. H. Beets-Tan,Steven W.M. Olde Damink,Steven W.M. Olde Damink,Toon Van Gorp,Toon Van Gorp +11 more
TLDR
This study investigates whether assessment of psoas muscle area reflects total muscle area and can be used to assess sarcopenia in ovarian cancer patients.Abstract:
BACKGROUND Computed tomography measurements of total skeletal muscle area can detect changes and predict overall survival (OS) in patients with advanced ovarian cancer This study investigates whether assessment of psoas muscle area reflects total muscle area and can be used to assess sarcopenia in ovarian cancer patients METHODS Ovarian cancer patients (n = 150) treated with induction chemotherapy and interval debulking were enrolled retrospectively in this longitudinal study Muscle was measured cross sectionally with computed tomography in three ways: (i) software quantification of total skeletal muscle area (SMA); (ii) software quantification of psoas muscle area (PA); and (iii) manual measurement of length and width of the psoas muscle to derive the psoas surface area (PLW) Pearson correlation between the different methods was studied Patients were divided into two groups based on the extent of change in muscle area, and agreement was measured with kappa coefficients Cox-regression was used to test predictors for OS RESULTS Correlation between SMA and both psoas muscle area measurements was poor (r = 052 and 039 for PA and PLW, respectively) After categorizing patients into muscle loss or gain, kappa agreement was also poor for all comparisons (all κ < 040) In regression analysis, SMA loss was predictive of poor OS (hazard ratio 1698 (95%CI 1038-2778), P = 0035) No relationship with OS was seen for PA or PLW loss CONCLUSIONS Change in psoas muscle area is not representative of total muscle area change and should not be used to substitute total skeletal muscle to predict survival in patients with ovarian cancerread more
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Sarcopenia: Revised European consensus on definition and diagnosis
Alfonso J. Cruz-Jentoft,Gulistan Bahat,Jürgen M. Bauer,Yves Boirie,Olivier Bruyère,Tommy Cederholm,Cyrus Cooper,Francesco Landi,Yves Rolland,Avan Aihie Sayer,Stéphane M. Schneider,Cornel C. Sieber,Eva Topinkova,Maurits Vandewoude,Marjolein Visser,Mauro Zamboni +15 more
TL;DR: An emphasis is placed on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarc Openia diagnosis, and provides clear cut-off points for measurements of variables that identify and characterise sarc openia.
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ESPEN guideline on clinical nutrition in liver disease.
Mathias Plauth,William Bernal,Srinivasan Dasarathy,Manuela Merli,Lindsay D. Plank,Tatjana Schütz,Stephan C. Bischoff +6 more
TL;DR: This update of evidence-based guidelines (GL) aims to translate current evidence and expert opinion into recommendations for multidisciplinary teams responsible for the optimal nutritional and metabolic management of adult patients with liver disease.
Journal ArticleDOI
Psoas as a sentinel muscle for sarcopenia: a flawed premise.
TL;DR: A quantitative comparison of total lumbar muscle area with the psoas area is provided, showing a large variance and was unrelated to the clinical outcome of overall survival, in patients with ovarian cancer.
Journal ArticleDOI
Implications of low muscle mass across the continuum of care: a narrative review
Carla M. Prado,Sarah A. Purcell,Carolyn Alish,Suzette L. Pereira,Nicolaas E. P. Deutz,Daren K. Heyland,Bret H. Goodpaster,Kelly A. Tappenden,Steven B. Heymsfield +8 more
TL;DR: A narrative review provides an overview of the importance of low muscle mass on health outcomes for patients in inpatient, outpatient and long-term care clinical settings and suggests techniques to identify and counteractLow muscle mass in clinical settings are needed.
Journal of Cachexia, Sarcopenia and Muscle
TL;DR: The Journal of Cachexia, Sarcopenia and Muscle is a high impact journal publishing quality articles covering body composition and muscle loss during the normal lifespan and as part of chronic disease progression, presenting research results, expert opinion and clinical innovation.
References
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Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care
Marina MourtzakisM. Mourtzakis,Carla M. Prado,Jessica R. Lieffers,Tony Reiman,Linda J. McCargar,Vickie E. Baracos +5 more
TL;DR: DXA-based analysis of fat and fat-free mass was performed in 50 cancer patients and compared with bioelectrical impedance analysis (BIA) and with regional computed tomography (CT) images available in the patients' medical records, finding CT presents great practical significance due to the prevalence of these images in patient diagnosis and follow-up.
Journal ArticleDOI
Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image
Wei Shen,Mark Punyanitya,ZiMian Wang,Dympna Gallagher,Marie-Pierre St.-Onge,Jeanine Albu,Steven B. Heymsfield,Stanley Heshka +7 more
TL;DR: Investigation of the relationships between abdominal SM and AT areas from single images and total body component volumes in a large and diverse sample of healthy adult subjects found that measurement of a single abdominal image can provide estimates of total bodySM and AT for group studies of healthy adults.
Journal ArticleDOI
Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO).
Andreas du Bois,Alexander Reuss,Eric Pujade-Lauraine,Philipp Harter,Isabelle Ray-Coquard,Jacobus Pfisterer +5 more
TL;DR: In this paper, an exploratory analysis was conducted of three prospective randomized trials (AGO-OVAR 3, 5, and 7) investigating platinum-taxane based chemotherapy regimens in advanced ovarian cancer conducted between 1995 and 2002.