Journal ArticleDOI
Quantitation in positron emission computed tomography: 1. Effect of object size.
TLDR
The effect of object size on the capability of positron emission computed tomography to measure isotope concentrations in a cross section was studied and measurements were found to be in good agreement with theoretical predictions for ideal systems of comparable resolution.Abstract:
The effect of object size on the capability of positron emission computed tomography to measure isotope concentrations in a cross section was studied. The relationship between the apparent isotope concentration in an image and the true concentration was measured as a function of object sizeread more
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Journal ArticleDOI
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method.
Michael E. Phelps,Michael E. Phelps,Sung-Cheng Huang,Sung-Cheng Huang,Edward J. Hoffman,Edward J. Hoffman,Carl Selin,Carl Selin,L. Sokoloff,L. Sokoloff,David E. Kuhl,David E. Kuhl +11 more
TL;DR: The data indicate that cerebral FDG‐6‐PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
Journal ArticleDOI
Partial-Volume Effect in PET Tumor Imaging
TL;DR: What PVE is and its consequences in PET tumor imaging are described; the parameters on which PVE depends are reviewed; and actions that can be taken to reduce the errors attributable to PVE are described.
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SUV: Standard Uptake or Silly Useless Value?
TL;DR: In many applications, subjective interpretation of PET images is actually superior to the use of quantitative data, and the field has continued to lean heavily toward numbers as the final arbiter of correctness.
Journal ArticleDOI
Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography
G. Di Chiro,R L DeLaPaz,Rodney A. Brooks,L. Sokoloff,Paul L. Kornblith,Barry H. Smith,Nicholas J. Patronas,Conrad V. Kufta,R. M. Kessler,Gerald S. Johnston,R. G. Manning,Alfred P. Wolf +11 more
TL;DR: A correlation between rate of glycolysis and malignancy in primary cerebral tumors is found and Cerebral cortical glucose utilization was often depressed in areas adjacent to or neurally connected to the tumor site, and there was focal irregular delta wave EEG activity in these areas.
Journal ArticleDOI
Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects.
Hans W. Müller-Gärtner,Jonathan M. Links,Jerry L. Prince,Robert 'Nick' Bryan,Elliot R. McVeigh,Jeffrey P. Leal,Christos Davatzikos,J. James Frost +7 more
TL;DR: In computer simulations and phantom studies, the GM PET algorithm permitted a 100% recovery of the actual tracer concentration in neocortical GM and hippocampus, irrespective of the GM volume, using an algorithm that relates the regional fraction of GM to partial volume effects.