Journal ArticleDOI
Quantitative estimation of diphenylhydantoin, primidone and phenobarbital in plasma by gas-liquid chromatography.
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TLDR
A gas-liquid Chromatographic method for the simultaneous determination of phenobarbital, primidone and diphenylhydantoin in human plasma following therapeutic doses has been developed and has the advantages of specificity, sensitivity and simple derivative formation.About:
This article is published in Clinica Chimica Acta.The article was published on 1970-08-01. It has received 219 citations till now.read more
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Standard Reference Materials: Srm 900, Antiepilepsy Drug Level Assay Standard
Richard G Christensen,Bruce Coxon,Barbara F. Howell,John Mandel,Robert C. Paule,Dennis J. Reeder,Robert Schaffer +6 more
TL;DR: This document describes development of methods and procedures used to produce and certify the Standard Reference Material (SRM), consisting of three serum samples, each to contain four antiepilepsy drugs at different concentrations.
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The Pharmacist’s Role in interpretation and Use of Anticonvulsant Serum Levels
TL;DR: Evaluating the use of anticonvulsant drug levels as interpreted by a pharmacist, and the effect upon drug therapy found that 146 levels were outside the therapeutic range.
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Therapeutic Drug Monitoring in Pediatric Practice: A Critical Appraisal
TL;DR: The prospects of clinical pharmacogenomics as therapeutic drug monitoring for the future in pediatric practice is quite promising.
Determinationof Serum DrugConcentrations
TL;DR: Another important limitation oftheradioimmu-noassay is thenecessity tophysically separate freeandantibody-bound label, increasing both cost and the possibility of introducing errors.
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Journal ArticleDOI
Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin.
TL;DR: The correlation is described between the serum level of diphenylhydantoin and the anticonvulsant effect of the drug, the incidence of paroxysmal abnormalities in the electroencephalogram, and the occurrence of toxic side-effects.
Journal Article
Studies on 5, 5'-diphenylhydantoin (dilantin) in animals and man.
TL;DR: In the rat, highest concentrations were found in the liver and fat, followed in order of decreasing concentration by the heart, spleen, kidney, lung and skeletal muscle, and red blood cells were found to contain Dilantin in approximately the same concentration as plasma.
Journal ArticleDOI
The rate of decline of diphenylhydantoin in human plasma
Keith Arnold,Nicholas Gerber +1 more
TL;DR: Saturation, autoinduction, or product inhibition, singly or in combination, of the drug‐metabolizing enzyme system are possible mechanisms involved in the dose dependency and nonexponential decline of plasma diphenylhydantoin concentration.
Journal ArticleDOI
Gas Chromatography of Barbiturates, Phenolic Alkaloids, and Xanthine Bases: Flash-Heater Methylation by Means of Trimethylanilinium Hydroxide
TL;DR: Injection of methanol solutions of trimethylanilinium salts of barbiturates, phenolic alkaloids, and dimethylxanthines produced thermal decomposition in the injection port to give methyl derivatives suitable for quantitative gas chromatography.