Journal ArticleDOI
Quantitative estimation of diphenylhydantoin, primidone and phenobarbital in plasma by gas-liquid chromatography.
Reads0
Chats0
TLDR
A gas-liquid Chromatographic method for the simultaneous determination of phenobarbital, primidone and diphenylhydantoin in human plasma following therapeutic doses has been developed and has the advantages of specificity, sensitivity and simple derivative formation.About:
This article is published in Clinica Chimica Acta.The article was published on 1970-08-01. It has received 219 citations till now.read more
Citations
More filters
Journal ArticleDOI
Accuracy of serum anticonvulsant measurements. A comparison of enzyme multiplied immunoassay technique and gas-liquid chromatography.
TL;DR: An enzyme multiplied immunoassay technique is compared with a gas-liquid chromatographic technique for the measurement in blood serum of the anticonvulsants phenytoin, carbamazepine, phenobarbitone, primidone, and ethosuximide.
Journal ArticleDOI
Phenytoin: Plasma levels and behavioral changes associated with suppression of auditory evoked potentials in the cat
TL;DR: PHT administration caused near total or total suppression of auditory evoked field potentials and brainstem auditory evoking potentials at mean plasma levels of 28.1–30.5 μg/ml, and this action may be mediated by effects on peripheral auditory receptor mechanisms.
Journal ArticleDOI
Determination of 5,5-diphenylhydantoin and its major metabolites in biological specimens by gas chromatography and selected ion-monitoring
M. Arboix,C. Pantarotto +1 more
TL;DR: The urinary elimination of 5,5-diphenylhydantoin and hydroxylated metabolites in male rats following a single intraperitoneal injection of the drug (25 mg/kg) are reported.
Journal ArticleDOI
Single extraction GLC analysis of six commonly prescribed antiepileptic drugs.
TL;DR: A simple gas-liquid chromatographic technique for the quantitation of ethosuximide, methsuximide (Celontin), mephobarbituate, phenobarbituates, primidone (Mysoline), and diphenylhydantoin (Dilantin) is described.
Journal ArticleDOI
A multiple dose study of mexiletine (Ko 1173)
James J. Cereghino,Joseph T. Brock,J. C. van Meter,J. K. Penry,Harvey J. Kupferberg,Lawrence D. Smith,B. G. White +6 more
TL;DR: A preliminary study of serum concentrations after multiple doses of mexiletine was performed with 8 institutionalized Caucasian adult males with uncontrolled seizures and similar weight, medical regimen, and seizure classification.
References
More filters
Journal ArticleDOI
Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin.
TL;DR: The correlation is described between the serum level of diphenylhydantoin and the anticonvulsant effect of the drug, the incidence of paroxysmal abnormalities in the electroencephalogram, and the occurrence of toxic side-effects.
Journal Article
Studies on 5, 5'-diphenylhydantoin (dilantin) in animals and man.
TL;DR: In the rat, highest concentrations were found in the liver and fat, followed in order of decreasing concentration by the heart, spleen, kidney, lung and skeletal muscle, and red blood cells were found to contain Dilantin in approximately the same concentration as plasma.
Journal ArticleDOI
The rate of decline of diphenylhydantoin in human plasma
Keith Arnold,Nicholas Gerber +1 more
TL;DR: Saturation, autoinduction, or product inhibition, singly or in combination, of the drug‐metabolizing enzyme system are possible mechanisms involved in the dose dependency and nonexponential decline of plasma diphenylhydantoin concentration.
Journal ArticleDOI
Gas Chromatography of Barbiturates, Phenolic Alkaloids, and Xanthine Bases: Flash-Heater Methylation by Means of Trimethylanilinium Hydroxide
TL;DR: Injection of methanol solutions of trimethylanilinium salts of barbiturates, phenolic alkaloids, and dimethylxanthines produced thermal decomposition in the injection port to give methyl derivatives suitable for quantitative gas chromatography.