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Open AccessJournal ArticleDOI

Quinupristin-Dalfopristin Nonsusceptibility in Pneumococci from Sickle Cell Disease Patients

Caroline Obert, +4 more
- 01 Jan 2007 - 
- Vol. 51, Iss: 1, pp 386-389
TLDR
Nonsusceptibilty to quinupristin-dalfopristin (Q-D) was absent from 105 non-SCD- associated pneumococcal isolates but was present in 33/148 SCD-associated isolates, and one-third of the isolates harbored a known resistance mechanism.
Abstract: 
Sickle cell disease (SCD) is a risk factor for fatal pneumococcal infection. Nonsusceptibilty to quinupristin-dalfopristin (Q-D) was absent from 105 non-SCD-associated pneumococcal isolates but was present in 33/148 (22%) SCD-associated isolates. One-third of the isolates harbored a known resistance mechanism. Q-D is not optimal for use for the treatment of pneumococcal infection in SCD patients.

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References
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Journal ArticleDOI

Bioedit: a user-friendly biological sequence alignment editor and analysis program for windows 95/98/ nt

Thomas A. Hall
- 01 Jan 1999 - 

Performance standards for antimicrobial susceptibility testing

Mary Jane. Ferraro
TL;DR: The supplemental information presented in this document is intended for use with the antimicrobial susceptibility testing procedures published in the following Clinical and Laboratory Standards Institute (CLSI)–approved standards.
Journal ArticleDOI

Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae

Hervé Tettelin, +38 more
- 20 Jul 2001 - 
TL;DR: A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low–guanine/cytosine Gram-positive species.
Journal ArticleDOI

Genome of the bacterium Streptococcus pneumoniae strain R6.

JoAnn Hoskins, +41 more
- 01 Oct 2001 - 
TL;DR: In the analysis of the genome, a large number of new uncharacterized genes predicted to encode proteins that either reside on the surface of the cell or are secreted are identified and there may be new targets for vaccine and antibiotic development.
Journal ArticleDOI

Identification of a Candidate Streptococcus pneumoniae Core Genome and Regions of Diversity Correlated with Invasive Pneumococcal Disease

Caroline Obert, +6 more
- 01 Aug 2006 - 
TL;DR: RDs are unequally distributed between invasive and noninvasive isolates, RD8a and RD10 are correlated with the propensity of an isolate to cause IPD, and PsrP is required for full virulence in mice.
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