Radiation-induced lung injury — what do we know in the era of modern radiotherapy?
TLDR
In this paper , the most critical patient and treatment-related predictors are summarized and discussed - age and sex, comorbidities, tumour characteristics, concomitant treatment, and RT-plan parameters.About:
This article is published in Reports of Practical Oncology & Radiotherapy.The article was published on 2022-03-31 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Medicine & Radiation therapy.read more
Citations
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Safety of hypofractionated volumetric modulated arc therapy for early breast cancer: A preliminary report
Jeong Won Lee,Mi Joo Chung +1 more
TL;DR: In this article , the authors evaluated the acute and subacute toxicities of hypofractionated volumetric modulated arc therapy (HFX-VMAT) in patients with early breast cancer (EBC).
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P38 MAPK and Radiotherapy: Foes or Friends?
Natalia García-Flores,J. Jiménez-Suárez,C. Garnés-García,Diego M. Fernández-Aroca,Sebastià Sabater,I. Andres,Antonio Fernández-Aramburo,María José Ruiz-Hidalgo,Borja Belandia,Ricardo Sánchez-Prieto,Francisco J. Cimas +10 more
TL;DR: The role of p38 MAPKs in the cellular response to ionizing radiation and radiotherapy is discussed in this paper , where the authors provide in-depth insights into what is known about the whole protein family's role in response to radiation and the implications for radiotherapy.
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Computed tomography and radiation dose images-based deep-learning model for predicting radiation pneumonitis in lung cancer patients after radiation therapy.
Zhen Zhang,Zhixiang Wang,Tiancheng Luo,Meng Yan,Andre Dekker,Dirk De Ruysscher,Alberto Traverso,Leonard Wee,Lu Jun Zhao +8 more
TL;DR: In this article , a deep learning model that combines CT and radiation dose (RD) images to predict the occurrence of radiation pneumonitis (RP) in lung cancer patients who received radical (chemo)radiotherapy was developed.
References
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Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer
Scott J. Antonia,A. Villegas,Davey B. Daniel,David Vicente,Shuji Murakami,Rina Hui,Takashi Yokoi,Alberto Chiappori,Ki Hyeong Lee,Maike de Wit,Byoung Chul Cho,M. Bourhaba,Xavier Quantin,Takaaki Tokito,Tarek Mekhail,David Planchard,Young-Chul Kim,Christos S. Karapetis,Sandrine Hiret,Gyula Ostoros,Kaoru Kubota,Jhanelle E. Gray,Luis Paz-Ares,Javier de Castro Carpeño,Catherine Wadsworth,Giovanni Melillo,Haiyi Jiang,Y. Huang,Phillip A. Dennis,Mustafa Ozguroglu,Pacific Investigators +30 more
TL;DR: Progression‐free survival was significantly longer with durvalumab than with placebo, and safety was similar between the groups, and the secondary end points also favored durvalsumab.
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An Official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias
William D. Travis,Ulrich Costabel,David M Hansell,Talmadge E. King,David A. Lynch,Andrew G. Nicholson,Christopher J. Ryerson,Jay H. Ryu,Moisés Selman,Athol U. Wells,Jurgen Behr,Demosthenes Bouros,Kevin K. Brown,Thomas V. Colby,Harold R. Collard,Carlos Robalo Cordeiro,Vincent Cottin,Bruno Crestani,Marjolein Drent,Rosalind F. Dudden,Jim Egan,Kevin R. Flaherty,Cory M. Hogaboam,Yoshikazu Inoue,Takeshi Johkoh,Dong Soon Kim,M Kitaichi,James E. Loyd,Fernando J. Martinez,Jeffrey L. Myers,Shandra Protzko,Ganesh Raghu,Luca Richeldi,Nicola Sverzellati,Jeffrey J. Swigris,Dominique Valeyre +35 more
TL;DR: This update is a supplement to the previous 2002 IIP classification document and outlines advances in the past decade and potential areas for future investigation.
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Meta-Analysis of Concomitant Versus Sequential Radiochemotherapy in Locally Advanced Non–Small-Cell Lung Cancer
Anne Auperin,Cécile Le Péchoux,Estelle Rolland,Walter J. Curran,Kiyoyuki Furuse,Pierre Fournel,José Belderbos,Gerald H. Clamon,Hakki Cuneyt Ulutin,Rebecca Paulus,Takeharu Yamanaka,Marie-Cecile Bozonnat,Apollonia L.J. Uitterhoeve,Xiaofei Wang,Lesley A. Stewart,Rodrigo Arriagada,Sarah Burdett,Jean-Pierre Pignon +17 more
TL;DR: Concomitant radiochemotherapy, as compared with sequential radiochemicalotherapy, improved survival of patients with locally advanced NSCLC, primarily because of a better locoregional control, but at the cost of manageable increased acute esophageal toxicity.
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Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial
Narek Shaverdian,Aaron Lisberg,Krikor Bornazyan,Darlene Veruttipong,Jonathan W. Goldman,Silvia C. Formenti,Edward B. Garon,Percy Lee +7 more
TL;DR: This trial aimed to assess disease control and pulmonary toxicity in patients who previously received radiotherapy for non-small-cell lung cancer (NSCLC) before receiving pembrolizumab to determine whether previous radiotherapy affected progression-free survival, overall survival, and pulmonaryoxicity in the intention-to-treat population.
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The International Epidemiology of Lung Cancer Geographical Distribution and Secular Trends
TL;DR: Given the increasing incidence of lung cancer in less developed countries and the current lack of effective treatment for advanced lung cancers, these results highlight the need for ongoing global tobacco reform to reduce the international burden of Lung cancer.