Journal ArticleDOI
Radioimmunoassay of cholecystokinin in human tissue and plasma.
TLDR
A highly sensitive radioimmunoassay for cholecystokinin (CCK) without any cross-reactivity with gastrin is described and when frozen at -20 degrees C plasma CCK was stable for at least 6 months.About:
This article is published in Clinica Chimica Acta.The article was published on 1983-07-15. It has received 237 citations till now. The article focuses on the topics: Cholecystokinin & Radioimmunoassay.read more
Citations
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Journal ArticleDOI
Bioassay of plasma cholecystokinin in rats: Effects of food, trypsin inhibitor, and alcohol
TL;DR: A specific, sensitive, and rapid bioassay for measuring plasma cholecystokinin in rats is reported, based on their ability to stimulate amylase release from isolated rat pancreatic acini.
Journal ArticleDOI
Accurate measurement of cholecystokinin in plasma
TL;DR: The results show that it is possible to produce specificCCK-antisera using a sulfated CCK-12 analog and that the antiserum binds the bioactive forms of CCK with equimolar potency and displays no reactivity with gastrin.
Journal ArticleDOI
Regulation of gastric emptying in humans by cholecystokinin.
TL;DR: Since exogenous CCK at concentrations which occur postprandially delays gastric emptying, it is concluded that CCK is a physiologic regulator of gastric emptiedying.
Journal ArticleDOI
Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility
Caroline G. MacIntosh,Jane M. Andrews,Karen L. Jones,Judith M. Wishart,Howard A. Morris,Jan B. M. J. Jansen,John E. Morley,Michael Horowitz,Ian Chapman +8 more
TL;DR: Human aging is associated with increased CCK concentrations, which may contribute to the slowing of gastric emptying, mediated by increased pyloric motility.
Journal ArticleDOI
Role of cholecystokinin in regulation of gastrointestinal motor functions.
BeatM. Meyer,Christoph Beglinger,JanB.M.J. Jansen,LucioC. Rovati,BaseliA. Werth,Pius Hildebrand,David Zach,G.A. Stalder +7 more
TL;DR: It is concluded that CCK is an important mediator of meal-induced gallbladder contraction and is involved in the regulation of gastrointestinal motility in man.
References
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Journal ArticleDOI
Cholecystokinin-Octapeptidelike Immunoreactivity in Human Plasma
TL;DR: It is likely that low concentrations of cholecystokinin peptides in the circulation interact with other factors such as enteropancreatic reflexes to produce normal postprandial stimulation of pancreatic enzyme secretion.
Journal ArticleDOI
Release of cholecystokinin in man: correlation of blood levels with gallbladder contraction.
TL;DR: Good correlation between concentrations of CCK and gallbladder size during both contraction and relaxation phases is demonstrated and future study of this correlation may be useful in patients with manifest dysfunction of thegallbladder, as well as in individuals known to be at risk of gallbladders disease.
Journal ArticleDOI
Identification and measurement of molecular variants of cholecystokinin in duodenal mucosa and plasma. Diminished concentrations in patients with celiac disease.
J. Calam,A. Ellis,G. J. Dockray +2 more
TL;DR: The amount and type of cholecystokinin (CCK) in duodenal extracts and plasma of celiac patients and normal subjects was studied by radioimmunoassay and gel filtration as mentioned in this paper.
Journal ArticleDOI
Radioimmunoassay of cholecystokinin in human plasma.
TL;DR: A sensitive radioimmunoassay for cholecystokinin (CCK) has been developed and raised against porcine CCK-33 covalently coupled to egg albumin with equimolar potency.
Journal ArticleDOI
Secretion pattern of secretin in man: regulation by gastric acid.
TL;DR: It is concluded that gastric acid in man does trigger release of secretin and that secretin is secreted intermittently both in the fasting state and in response to a meal when boluses of acid enter the duodenum.
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Identification and measurement of molecular variants of cholecystokinin in duodenal mucosa and plasma. Diminished concentrations in patients with celiac disease.
J. Calam,A. Ellis,G. J. Dockray +2 more