Randomized study to evaluate Sirolimus-eluting stents implanted at coronary bifurcation lesions
Antonio Colombo,Jeffrey W. Moses,Marie Claude Morice,Josef Ludwig,David R. Holmes,Vassilis Spanos,Yves Louvard,Benny Desmedt,Carlo Di Mario,Martin B. Leon +9 more
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TLDR
These results are an improvement compared with historical controls using bare metal stents in coronary bifurcation lesions, but restenosis at the SB remains a problem.Abstract:
Background— A sirolimus-eluting stent (Cypher, Cordis Corp) has been reported to markedly decrease restenosis in selected lesions; higher-risk lesions, including coronary bifurcations, have not been studied. Methods and Results— This prospective study evaluated the safety and efficacy of sirolimus-eluting stents for treatment of coronary bifurcation lesions. Patients were randomly assigned to either stenting of both branches (group A) or stenting of the main branch with provisional stenting of the side branch (SB) (group B). Eighty-five patients (86 lesions) were enrolled. There was 1 case of unsuccessful delivery of any device at the bifurcation site. Given the high crossover, more lesions were treated with 2 stents (n=63) than with stent/balloon (n=22). Clinical follow-up at 6 months was completed in all patients and angiographic follow-up in 53 patients in group A (85.5%) and 21 in group B (95.4%). One patient died suddenly 4.5 months after the procedure. There were 3 cases of stent thrombosis (3.5%). ...read more
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2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI).
Stephan Windecker,Philippe Kolh,Fernando Alfonso,Jean-Philippe Collet,Jochen Cremer,Volkmar Falk,Gerasimos Filippatos,Christian W. Hamm,Stuart J. Head,Peter Jüni,A. Pieter Kappetein,Adnan Kastrati,Juhani Knuuti,Ulf Landmesser,Günther Laufer,Franz-Josef Neumann,Dimitrios J. Richter,Patrick Schauerte,Miguel Sousa Uva,Giulio G. Stefanini,David P. Taggart,Lucia Torracca,Marco Valgimigli,William Wijns,Adam Witkowski +24 more
TL;DR: Neumann et al. as discussed by the authors proposed a task force to evaluate the EACTS Review Co-ordinator's work on gender equality in the context of women's reproductive health.
Journal ArticleDOI
Coronary Artery Stents
Pepine Cj,Holmes Dr +1 more
TL;DR: The indications for and biology of coronary-artery stents are reviewed, focusing on recent advances in drug-eluting stents.
Journal ArticleDOI
Randomized study on simple versus complex stenting of coronary artery bifurcation lesions: the Nordic bifurcation study
Terje K. Steigen,Michael Maeng,Rune Wiseth,Andrejs Erglis,Indulis Kumsars,Inga Narbute,Pål Gunnes,Jan Mannsverk,Oliver Meyerdierks,Svein Rotevatn,Matti Niemelä,Kari Kervinen,Jan Skov Jensen,Anders Galløe,Kjell Nikus,Saila Vikman,Jan Ravkilde,Stefan James,Jens Aarøe,Antti Ylitalo,Steffen Helqvist,Iwar Sjögren,Per Thayssen,Kari S. Virtanen,Mikko Puhakka,Juhani Airaksinen,Jens Flensted Lassen,Leif Thuesen +27 more
TL;DR: The simple stenting strategy used in the MV group was associated with reduced procedure and fluoroscopy times and lower rates of procedure-related biomarker elevation, and can be recommended as the routine bifurcation stenting technique.
Journal ArticleDOI
Coronary-artery stents.
TL;DR: A review of the indications for and biology of coronary-artery stents, focusing on recent advances in drug-eluting stents is given in this article. But, most published data originated in the era of bare-metal stents.
Journal ArticleDOI
Sirolimus-eluting stent or paclitaxel-eluting stent vs balloon angioplasty for prevention of recurrences in patients with coronary in-stent restenosis: a randomized controlled trial.
Adnan Kastrati,Julinda Mehilli,Nicolas von Beckerath,Alban Dibra,Jörg Hausleiter,Jürgen Pache,Helmut Schühlen,Claus Schmitt,Josef Dirschinger,Albert Schömig +9 more
TL;DR: In patients with in-stent restenosis, a strategy based on sirolimus- or paclitaxel-eluting stents is superior to conventional balloon angioplasty for the prevention of recurrent restenotic.
References
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Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery.
Jeffrey W. Moses,Martin B. Leon,Jeffrey J. Popma,Peter J. Fitzgerald,David R. Holmes,Charles O'Shaughnessy,Ronald P. Caputo,Dean J. Kereiakes,David O. Williams,Paul S. Teirstein,Judith Jaeger,Richard E. Kuntz +11 more
TL;DR: In this randomized clinical trial involving patients with complex coronary lesions, the use of a sirolimus-eluting stent had a consistent treatment effect, reducing the rates of restenosis and associated clinical events in all subgroups analyzed.
Journal ArticleDOI
A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization
Marie-Claude Morice,Patrick W. Serruys,J. Eduardo Sousa,Jean Fajadet,Ernesto Ban Hayashi,Marco Antonio Perin,Antonio Colombo,Gerhard Schuler,Paul Barragan,Giulio Guagliumi,Ferenc Molnar,Robert Falotico +11 more
TL;DR: As compared with a standard coronary stent, a sirolimus-eluting stent shows considerable promise for the prevention of neointimal proliferation, restenosis, and associated clinical events.
Journal ArticleDOI
Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade.
TL;DR: Platelet glycoprotein-IIb/IIIa blockade with abciximab substantially improves the safety of coronary-stenting procedures and is safer than stenting without abcximab.
Journal ArticleDOI
Randomised placebo-controlled and balloon-angioplasty- controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade
TL;DR: Platelet glycoprotein-IIb/IIIa blockade with abciximab substantially improves the safety of coronary-stenting procedures and is safer than stenting without abcximab.
Journal ArticleDOI
Lack of Neointimal Proliferation After Implantation of Sirolimus-Coated Stents in Human Coronary Arteries: A Quantitative Coronary Angiography and Three-Dimensional Intravascular Ultrasound Study
J. Eduardo Sousa,Marco A. Costa,Alexandre Abizaid,Andrea Abizaid,Fausto Feres,Ibraim Francisco Pinto,Ana C. Seixas,Rodolfo Staico,Luiz Alberto Mattos,Amanda G. M. R. Sousa,Robert Falotico,Judith Jaeger,Jeffrey J. Popma,Patrick W. Serruys +13 more
TL;DR: In this article, the safety and efficacy of sirolimus-coated BX Velocity stents were evaluated in 30 patients with angina pectoris electively treated with two different formulations of SIROlimuscoated stents (slow release and fast release).
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