Rare diseases bullet 8: Organising pneumonia
TLDR
This terminology is preferred to the other name used for this condition—namely, idiopathic bronchiolitis obliterans with organising pneumonia (BOOP)—which may be confused with other types of Bronchiolar disorders, particularly constrictive bronchiola obliterans which is mainly characterised by airflow obstruction.Abstract:
Organising pneumonia is defined pathologically by the presence in the distal air spaces of buds of granulation tissue progressing from fibrin exudates to loose collagen containing fibroblasts (fig 1). 2 The lesions occur predominantly within the alveolar spaces but are often associated with buds of granulation tissue occupying the bronchiolar lumen (bronchiolitis obliterans). This pathological pattern is not specific for any disorder or cause, but reflects one type of inflammatory process resulting from lung injury. It may also be a feature of the organising stage of adult respiratory distress syndrome and may be an accessory finding in other inflammatory disorders such as vasculitis. However, organising pneumonia is the particular pathological hallmark of a characteristic clinicoradiological entity called cryptogenic organising pneumonia. This terminology is preferred to the other name used for this condition—namely, idiopathic bronchiolitis obliterans with organising pneumonia (BOOP)—which may be confused with other types of bronchiolar disorders, particularly constrictive bronchiolitis obliterans which is mainly characterised by airflow obstruction.read more
Citations
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Journal ArticleDOI
Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society.
Athol U. Wells,Nik Hirani +1 more
TL;DR: Since the publication of the first BTS guidelines for diffuse lung disease nearly 10 years ago, the specialty has seen considerable change and has led to a radical change in accepted diagnostic gold standards, which have become increasingly multidisciplinary and dependent equally upon the skills of pathologists, radiologists and clinicians.
Journal Article
Bronchiolitis obliterans with organizing pneumonia
TL;DR: A typical case of Obliterant Bonchilitis with Organizative Pneumonia in a 73-years-old man with high dosage of methylprednisolone is presented.
Journal ArticleDOI
Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation.
TL;DR: Pulmonary complications develop in 30–60% of hematopoietic stem cell transplants (HSCT) and the main, late onset, non-infectious complications include Bronchiolitis obliterans (BO), Bronchiola obliterans organizing pneumonia (BOOP), and idiopathic pneumonia syndrome (IPS).
Journal ArticleDOI
Bronchiolitis Obliterans Organizing Pneumonia
TL;DR: The clinical findings and therapeutic management of bronchiolitis obliterans organizing pneumonia are reviewed.
Journal ArticleDOI
Pulmonary pathological features in coronavirus associated severe acute respiratory syndrome (SARS).
Gary Man-Kit Tse,Ka Fai To,Paul K.S. Chan,Anthony W.I. Lo,King Cheung Ng,Angela Wu,Nelson Lee,H. C. Wong,S. M. Mak,K. F. Chan,David S.C. Hui,Joseph J.Y. Sung,Ho Keung Ng +12 more
TL;DR: Postmortem examination allows tissue to be sampled for virological investigations and ultrastructural examination, and when coupled with the appropriate lung morphological changes, is valuable to confirm the diagnosis of SARS-CoV, particularly in clinically unapparent or suspicious but unconfirmed cases.
References
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Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.
Dylan R. Edwards,G. Murphy,J. J. Reynolds,S. E. Whitham,A. J. P. Docherty,P. Angel,John K. Heath +6 more
TL;DR: The observations suggest that TGF‐beta exerts a selective effect on extracellular matrix deposition by modulating the action of other growth factors on metalloproteinase and TIMP expression.
Journal ArticleDOI
Bronchiolitis obliterans organizing pneumonia.
TL;DR: In 50 of 94 patients with bronchiolitis obliterans, the authors found no apparent cause or associated disease, and the bronchiola obliterans occurred with patchy organizing pneumonia, which was confused most often with idiopathic pulmonary fibrosis.
Journal ArticleDOI
A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis
Loïc Guillevin,Jean-François Cordier,Franïois Lhote,Pascal Cohen,Bernard Jarrousse,Isabelle Royer,Philippe Lesavre,Christian Jacquot,Pascal Bindi,Philippe Bielefeld,Jean-Franïois Desson,Frédérick Détrée,Alain Dubois,Eric Hachulla,Bruno Hoen,Dominique Jacomy,Christian Seigneuric,Dominique Lauque,Marc Stern,Maité Longy-Boursier +19 more
TL;DR: Pulse CYC is as effective as oral CYC in achieving initial remission of WG and is associated with fewer side effects and lower mortality, however, in the long term, treatment with pulse CYC does not maintain remission or prevent relapses as well as Oral CYC.
Journal ArticleDOI
An immunohistochemical study of architectural remodeling and connective tissue synthesis in pulmonary fibrosis.
TL;DR: Fibrosis in chronic idiopathic pulmonary fibrosis results mainly from organization of exudate within airspaces, just as it does after acute lung injury, and during this process, fibroblasts increase their synthesis of collagen and fibronectin coordinately.
Journal Article
Bronchiolitis obliterans with organizing pneumonia
TL;DR: A typical case of Obliterant Bonchilitis with Organizative Pneumonia in a 73-years-old man with high dosage of methylprednisolone is presented.
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