Rates of removal and degradation of chylomicron remnants by isolated perfused rat liver.
Allen D. Cooper,P. Y. S. Yu +1 more
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TLDR
Feeding the liver donors a diet containing 1% cholesterol or 4% cholesterol and 1% cholic acid failed to alter the hepatic removal rate and the cholesteryl ester removed from the remnants was hydrolyzed at a rate that was a small fraction of the removal rate.About:
This article is published in Journal of Lipid Research.The article was published on 1978-07-01 and is currently open access. It has received 86 citations till now. The article focuses on the topics: Chylomicron remnant & Cholesteryl ester.read more
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Journal ArticleDOI
Atherogenesis: a postprandial phenomenon.
TL;DR: Evidence is presented that in humans, and experimental animals, chylomicron remnants as well as low-density lipoproteins are taken up by arterial cells, indicating atherogenesis may occur during the postprandial period.
Journal ArticleDOI
Regulation of plasma cholesterol by lipoprotein receptors
TL;DR: The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man.
Journal ArticleDOI
Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein
TL;DR: It is concluded that lipoprotein lipase strongly enhances the binding of apoE-containing lipoproteins to LRP and therefore might play an important role in chylomicron catabolism not only because of its lipolytic activity but alsoBecause of its structural properties.
Journal ArticleDOI
Hepatic uptake of chylomicron remnants.
TL;DR: In humans, delayed removal of chylomicron remnants has been documented in diabetes, renal failure, and familial combined hyperlipemia and is the abnormality resulting in type III hyperlipidemia.
Journal ArticleDOI
Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins.
E Windler,Y. S. Chao,R J Havel +2 more
TL;DR: The results are consistent with the hypothesis that changes in apolipoprotein composition of triglyceride-rich lipoproteins that occur as they are secreted from intestine and liver and as they is subsequently metabolized can explain both the lack of initial hepatic uptake and the subsequent rapid liver uptake and catabolism of remnant lipoproteinins.
References
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Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture
TL;DR: The data suggest a reciprocal relationship between insulin in the extracellular fluid and the concentration of insulin receptors per cell, which is mediated at the target cell itself by intracellular insulin-sensitive regulatory processes and directly affects target-cell sensitivity to hormone.
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Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, beta-glucuronidase and cathepsin by rat-liver particles.
R. Gianetto,C. De Duve +1 more
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Formation of cholesteryl ester-rich particulate lipid during metabolism of chylomicrons
TL;DR: The hypothesis that the first step in chylomicron metabolism occurred in extrahepatic tissues where a large portion of the triglyceride was removed by the action of lipoprotein lipase is consistent.