Journal ArticleDOI
Reaction Engineering of Biocatalytic Enantioselective Reduction: A Case Study for Aliphatic Ketones
TLDR
In this paper, a cost analysis revealed that the enzyme costs are negligible, but the cost for nicotinamide cofactor NADP+ is dominating the overall cost of the chemical raw material followed by the ionic liquid (TEGO IL K5) used as solubiliser and the buffer.About:
This article is published in Organic Process Research & Development.The article was published on 2013-07-25. It has received 14 citations till now. The article focuses on the topics: Green chemistry.read more
Citations
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Journal ArticleDOI
Application of Enzyme Coupling Reactions to Shift Thermodynamically Limited Biocatalytic Reactions
TL;DR: This mini‐review focuses on enzyme coupling reactions as a tool to alleviate thermodynamic constraints in synthetically useful biocatalytic reactions and the implications of thermodynamic parameters such as the equilibrium constant on the multi‐enzyme cascades and the conventional methods of equilibrium shifting are discussed.
Journal ArticleDOI
A two-step biocatalytic cascade in micro-aqueous medium: using whole cells to obtain high concentrations of a vicinal diol
Andre Jakoblinnert,Dörte Rother +1 more
TL;DR: A synthetic cascade approach in which lyophilised, recombinant whole cells are applied in micro-aqueous reaction systems yielding extremely high space-time-yields and an efficient two-step cascade for the production of 1-phenylpropane-1,2-diol.
Journal ArticleDOI
Simulation and analysis of the performance of tubular enzymatic membrane reactors under different configurations, kinetics and mass transport conditions
R. Abejón,Cristiana Luminiţa Gîjiu,Marie-Pierre Belleville,Delphine Paolucci-Jeanjean,José Sanchez-Marcano +4 more
TL;DR: The simulated results demonstrated that the most significant variable of the global performance of the enzymatic membrane reactors is the reaction kinetics: fast reactions attained very considerable conversion values under very different conditions.
Journal ArticleDOI
Redox metabolism for improving whole-cell P450-catalysed terpenoid biosynthesis
TL;DR: In this article, the potential of redox state as crucial regulator of P450 biocatalysis has been greatly underestimated by the scientific community, and they re-emphasize their pivotal role in modulating the in vivo P450 activity through affecting the product profile and yield.
Journal ArticleDOI
Cascade enzymatic synthesis of L-homoserine – mathematical modelling as a tool for process optimisation and design
Morana Česnik,Martina Sudar,Karel Hernández,Simon J. Charnock,Đurđa Vasić-Rački,Pere Clapés,Z. Findrik Blažević +6 more
TL;DR: The one-pot cascade synthesis of L-homoserine with substrate recycling catalysed by an aldolase and a transaminase was investigated in detail, with special interest in the reaction's kinetics and process development.
References
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Journal ArticleDOI
The atom economy--a search for synthetic efficiency
TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
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Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo‐ and Stereoselective Hydrogenation of Ketones
Ryoji Noyori,Takeshi Ohkuma +1 more
TL;DR: The newly devised [RuCl(2)(phosphane)(2)(1,2-diamine)] complexes are excellent precatalysts for homogeneous hydrogenation of simple ketones which lack any functionality capable of interacting with the metal center.
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Asymmetric Catalysis: Science and Opportunities (Nobel Lecture)
TL;DR: Asymmetric catalysis, in its infancy in the 1960s, has dramatically changed the procedures of chemical synthesis, and resulted in an impressive progression to a level that technically approximates or sometimes even exceeds that of natural biological processes as discussed by the authors.
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The E Factor: fifteen years on
TL;DR: In this article, the effect of the E Factor concept has had over the last fifteen years on developments in the chemical industry and pharmaceutical industry with regard to waste minimisation and to assess its current status in the broader context of green chemistry and sustainability.
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Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation
Kim Alfonsi,Juan Colberg,Peter J. Dunn,Thomas Lee Fevig,Sandra M. Jennings,Johnson Timothy Allan,H. Peter Kleine,Craig J. Knight,Mark A. Nagy,David Austen Perry,Mark H. Stefaniak +10 more
TL;DR: In this article, the authors describe the development of two of those education tools, which are used to influence and improve the environmental performance of a large multi-national pharmaceutical company by using electronic education tools.