Journal ArticleDOI
Reactions of oxidized thioureas with amine nucleophiles1
TLDR
In this paper, a route for the convenient, cost effective synthesis of di-and tri-substituted guanidines from thioureas has been developed.Abstract:
A route for the convenient, cost effective synthesis of di- and tri-substituted guanidines from thioureas has been developed. The key transformation involves activation of the sulfur through S-oxidation followed by displacement of the activated sulfur by an amine nucleophile (oxidation/displacement). This preparation is experimentally facile and results in good isolated yields of desired guanidines. No noxious substances or sensitive intermediates are generated. The reaction time is short and overall yield of desired guanidine from thiourea is good.read more
Citations
More filters
Journal ArticleDOI
Recent trends in the chemistry of sulfur-containing reducing agents
TL;DR: In this article, the structure, synthesis, stability and reactivity of sulfur-containing reducing agents with C-S or S-S bonds are surveyed and the applications of these compounds in the studies of nonlinear phenomena in chemical kinetics and in guanidine syntheses are considered.
Journal ArticleDOI
Solid-Phase Synthesis of Deoxynucleic Guanidine (DNG) Oligomers and Melting Point and Circular Dichroism Analysis of Binding Fidelity of Octameric Thymidyl Oligomers with DNA Oligomers
TL;DR: In this paper, a solid-phase synthesis of deoxynucleic guanidine (DNG), a positively charged DNA backbone analogue, is reported, where the nucleoside coupling step in the solid phase synthesis of DNG involves the attack of a terminal 3'-amine upon an electronically activated 5'-carbodiimide to create a protected guanidinium internucleoside linkage.
Journal ArticleDOI
Recent Developments in the Chemistry of Thiourea Oxides
TL;DR: The review gives a detailed survey of the latest developments and main trends in the chemistry and application of thiourea mon-, di-, and trioxides.
Journal ArticleDOI
Structure and stability of aminoiminomethanesulfonic acid
Sergei V. Makarov,Claudius Mundoma,John H. Penn,Jeffrey L. Petersen,Serge A. Svarovsky,Reuben H. Simoyi +5 more
TL;DR: The crystal structure of aminoiminomethanesulfonic acid (AIMSOA), (NH2)2CSO3, was determined by X-ray crystallography as mentioned in this paper.
Journal ArticleDOI
Oxidation and decomposition kinetics of thiourea oxides.
TL;DR: Experiments illustrate that the decomposition of thiourea oxides is a first-order reaction, in which the rate constants increase with the pH of the solution, which shows that increasing the pHof the reaction solution significantly accelerates the oxidation process.
References
More filters
Journal ArticleDOI
Advances in the chemistry of carbodiimides.
Book
The Organic Chemistry of Drug Synthesis
TL;DR: The Organic Chemistry of Drug Synthesis as mentioned in this paper, The organic chemistry of drug synthesis, The organic Chemistry of drug synthesization, The Organic Chemistry, Synthesis, and Synthesis.
Journal ArticleDOI
Recent developments in the carbodiimide chemistry
Journal ArticleDOI
Säureamid-Reaktionen, XXVII. Umsetzungen mit Säureamid-Phosphoroxychlorid-Addukten und Amidchloriden
Hellmut Bredereck,Karl Bredereck +1 more
TL;DR: Aus Saureamid-Phosphoroxychlorid-Komplexen und Aminen werden Amidine hergestellt in Gegenwart von Phosphoroxchlorid Guanidine as discussed by the authors.