Journal ArticleDOI
Recent advances in the chemistry and biochemistry of cannabis
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This article is published in Chemical Reviews.The article was published on 1976-02-01. It has received 175 citations till now.read more
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Phytocannabinoids: a unified critical inventory.
Lumir Hanus,Stefan Martin Meyer,Eduardo Muñoz,Orazio Taglialatela-Scafati,Giovanni Appendino +4 more
TL;DR: The integrated inventory of these compounds and their biological macromolecular end-points highlights the opportunities that phytocannabinoids offer to access desirable drug-like space beyond the one associated to the narcotic target CB1.
Journal ArticleDOI
Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
Giovanni Appendino,Simon Gibbons,Anna Giana,Alberto Pagani,Gianpaolo Grassi,Michael Stavri,Eileen Smith,M. Mukhlesur Rahman +7 more
TL;DR: Observations suggest that the prenyl moiety of cannabinoids serves mainly as a modulator of lipid affinity for the olivetol core, a per se poorly active antibacterial pharmacophore, while their high potency definitely suggests a specific, but yet elusive, mechanism of activity.
Journal ArticleDOI
Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients
Jomar M. Cunha,Elisaldo Araujo Carlini,Aparecido E. Pereira,Oswaldo L. Ramos,Camilo Pimentel,Rubens Gagliardi,Wilson Luiz Sanvito,N. Lander,Raphael Mechoulam +8 more
TL;DR: Four of the 8 CBD subjects remained almost free of convulsive crises throughout the experiment and 3 other patients demonstrated partial improvement in their clinical condition, while CBD was ineffective in 1 patient.
Journal ArticleDOI
Visible light photocatalysis of [2+2] styrene cycloadditions by energy transfer.
Zhan Lu,Tehshik P. Yoon +1 more
TL;DR: In contrast to previous reports of visible light photoredox catalysis, the mechanism of this process involves photosensitization by energy transfer and not electron transfer.
Journal ArticleDOI
Early phytocannabinoid chemistry to endocannabinoids and beyond
TL;DR: There have since been considerable advances in understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.
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