Journal ArticleDOI
Regulation of natural killer activity in vivo. II. The effect of alcohol consumption on human peripheral blood natural killer activity
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Changes in T cell, B cell or macrophage populations, therefore, are not the mechanism for increased NK activity in alcoholics.Abstract:
Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4-h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in the control group. NK activity of PBL from alcoholics was still higher than that of similarly treated PBL from control subjects after carbonyl iron and magnet treatment, or after passage through a nylon wool column or after removal of cells rosetting with sheep erythrocytes. Changes in T cell, B cell or macrophage populations, therefore, are not the mechanism for increased NK activity in alcoholics.read more
Citations
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Journal ArticleDOI
Alcohol and Immune Defense
TL;DR: The impact on health includes increased morbidity from cirrhosis, gastrointestinal hemorrhage, trauma, cancer, and infection, and factors that contribute to the high incidence of infection among alcoholics include dulled mental function, breakdown of local protective barriers, aspiration, exposure, and malnutrition.
Journal ArticleDOI
Reduction of immune function in life stress and depression.
Michael R. Irwin,Thomas L. Patterson,Tom L. Smith,Cindy Caldwell,Sandra A. Brown,J. Christian Gillin,Igor Grant +6 more
TL;DR: Findings of altered immunity provide further evidence that the physiological responses in chronic stress parallel those found in the syndrome of depression.
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The Effect of Mirthful Laughter on Stress and Natural Killer Cell Activity
TL;DR: Laughter may reduce stress and improve NK cell activity, and may be a useful cognitive-behavioral intervention in persons with cancer and HIV disease.
Journal ArticleDOI
Major depressive disorder, alcoholism, and reduced natural killer cell cytotoxicity. Role of severity of depressive symptoms and alcohol consumption.
Michael R. Irwin,Cindy Caldwell,Tom L. Smith,Sandra A. Brown,Marc A. Schuckit,J. Christian Gillin +5 more
TL;DR: While both depression and alcoholism are separately associated with a reduction of natural Killer cell activity, subgroups of patients in whom the diagnoses of alcoholism and depression coexist show a further decrement in natural killer cell function.
Journal ArticleDOI
Alcoholism: Independent Predictor of Survival in Patients With Head and Neck Cancer
TL;DR: The results suggest that sobriety among alcoholic patients can lead to prolonged survival, and alcohol abuse, measured by alcohol consumption, functional impairment, a history of alcohol-related health problems, or abstinence, can provide important prognostic information for patients with head and neck cancer.
References
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TL;DR: A rapid method is described for effectively removing immunoglobulin‐bearing cells from either primed or unprimed mouse spleen and lymph node cell suspensions.
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The glomerular permeability determined by dextran clearance using Sephadex gel filtration.
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Book ChapterDOI
Natural Cell-Mediated Immunity
TL;DR: This chapter summarizes the known information on the expression of natural cytotoxicity in rodents and in man, its specificity, the nature of the effector cells and their relationship to other immune mechanisms, and the possible in vivo relevance ofnatural cytotoxic relevance, particularly in regard to resistance against tumor growth.
Journal Article
Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: characterization of effector cells.
TL;DR: The data indicate that the cytotoxic lymphocyte in this system is Fc receptor positive, largely complement receptor negative, and may possess low density or low affinity receptors for SRBC.