Journal ArticleDOI
Relation of human papilloma virus status to cervical lesions and consequences for cervical-cancer screening: a prospective study
M A E Nobbenhuis,Jan M. M. Walboomers,Theo J.M. Helmerhorst,Lawrence Rozendaal,A. J. Remmink,Elle K.J. Risse,Hans C. van der Linden,Feja J. Voorhorst,Peter Kenemans,Chris J.L.M. Meijer +9 more
TLDR
Persistent infection with high-risk human papillomavirus is necessary for development and maintenance of cervical intraepithelial neoplasia CIN 3, and all women with severe dyskaryosis should be referred to gynaecologists, whereas women with mild to moderate dysKaryosis ought to be referred only after a second positive test for high- risk human papillsomav virus at 6 months.About:
This article is published in The Lancet.The article was published on 1999-07-03. It has received 692 citations till now. The article focuses on the topics: Cervical intraepithelial neoplasia & Dyskaryosis.read more
Citations
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Journal ArticleDOI
The causal relation between human papillomavirus and cervical cancer
TL;DR: It is the right time for medical societies and public health regulators to consider the causal role of human papillomavirus infections in cervical cancer and to define its preventive and clinical implications.
Journal ArticleDOI
A controlled trial of a human papillomavirus type 16 vaccine.
Laura A. Koutsky,Kevin A. Ault,Cosette M. Wheeler,Darron R. Brown,Eliav Barr,Frances B. Alvarez,Lisa M. Chiacchierini,Kathrin U. Jansen +7 more
TL;DR: Administration of this HPV- 16 vaccine reduced the incidence of both HPV-16 infection and HPV-15-related cervical intraepithelial neoplasia, and immunizing HPV-14-negative women may eventually reduce the probability of cervical cancer.
A controlled trial of a human papillomavirus type 16 vaccine
L Aura A. K Outsky,K Evin A. A Ult,C Osette M. W Heeler,D Arron R. B Rown,E Liav B Arr,F Rances B. A Lvarez,L Isa M. C Hiacchierini,And K Athrin,U. J Ansen +8 more
Journal ArticleDOI
Improved Amplification of Genital Human Papillomaviruses
Patti E. Gravitt,Cheri L. Peyton,T. Q. Alessi,Cosette M. Wheeler,François Coutlée,Allan Hildesheim,Mark Schiffman,David R. Scott,Raymond J. Apple +8 more
TL;DR: The redesigned MY09/11 primers were redesigned to increase the sensitivity of amplification across the type spectrum by using the same primer binding regions in the L1 open reading frame, and affords an increase in type-specific amplification sensitivity over that of the standard MY 09/11 primer system.
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Overview of the European and North American studies on HPV testing in primary cervical cancer screening.
Jack Cuzick,Christine Clavel,Karl Ulrich Petry,Chris J.L.M. Meijer,Heike Hoyer,Sam Ratnam,Anne Szarewski,Philippe Birembaut,Shalini L Kulasingam,Peter Sasieni,Thomas Iftner +10 more
TL;DR: The results support the use of HPV testing as the sole primary screening test, with cytology reserved for women who test HPV positive, with large demonstration projects needed to fully evaluate this strategy.
References
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Journal ArticleDOI
Human papillomavirus is a necessary cause of invasive cervical cancer worldwide.
Jan M. M. Walboomers,M. V. Jacobs,M. M. Manos,Franz X. Bosch,J. A. Kummer,Keerti V. Shah,Peter J.F. Snijders,Julian Peto,Chris J.L.M. Meijer,Nubia Muñoz +9 more
TL;DR: The presence of HPV in virtually all cervical cancers implies the highest worldwide attributable fraction so far reported for a specific cause of any major human cancer, and the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening.
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Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective
Francesc Xavier Bosch,M. M. Manos,Nubia Muñoz,Mark E. Sherman,Angela M. Jansen,Julian Peto,Mark Schiffman,Victor Moreno,Robert J. Kurman,Keerti V. Shah +9 more
TL;DR: The results confirm the role of genitalHPVs, which are transmitted sexually, as the central etiologic factor in cervical cancer worldwide and suggest that most genital HPVs are associated with cancer, at least occasionally.
Journal ArticleDOI
Natural history of cervicovaginal papillomavirus infection in young women
TL;DR: An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race, an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristics of partners.
Journal ArticleDOI
The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR.
Ana-Maria de Roda Husman,Jan M. M. Walboomers,Adriaan J. C. van den Brule,Chris J.L.M. Meijer,Peter J.F. Snijders +4 more
TL;DR: The data indicate that the GP5+/6+ PCR method provides an increased detection level mainly of uncommon, apparently poorly matched HPV types in cervical scrapes and most likely in the enlargement of the spectrum of HPVs detectable by this assay.
Journal ArticleDOI
Epidemiologic Evidence Showing That Human Papillomavirus Infection Causes Most Cervical Intraepithelial Neoplasia
Mark Schiffman,Heidi M. Bauer,Robert N. Hoover,Andrew G. Glass,Diane M. Cadell,Brenda B. Rush,David R. Scott,Mark E. Sherman,Robert J. Kurman,Sholom Wacholder,Cynthia K. Stanton,M. Michele Manos +11 more
TL;DR: The data show that the great majority of all grades of CIN can be attributed to HPV infection, particularly with the cancer-associated types of HPV.