Journal ArticleDOI
Relationship of Selenium to Cancer. I. Inhibitory Effect of Selenium on Carcinogenesis
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This article is published in Journal of the National Cancer Institute.The article was published on 1970-04-01. It has received 263 citations till now. The article focuses on the topics: Selenium.read more
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Journal ArticleDOI
Antioxidants/antimutagens in food.
TL;DR: Several reports have suggested that lipid peroxidation may result in destabilization and disintegration of cell membranes, leading to liver injury and other diseases, and finally, to aging and susceptibility to cancer.
Journal ArticleDOI
Chemopreventive agents: selenium.
Gerald F. Combs,William P. Gray +1 more
TL;DR: According to this two-stage model of the roles of Se in cancer prevention, individuals with nutritionally adequate Se intakes may benefit from Se supplementation and the development of the potential of Se compounds as cancer chemopreventive agents is facilitated.
Journal ArticleDOI
Multistage carcinogenesis in mouse skin
TL;DR: The mouse skin model of multistage carcinogenesis has for many years provided a conceptual framework for studying carcinogenesis mechanisms and potential means for inhibiting specific stages of carcinogenesis, and a summary of known inhibitors of specific stages and their proposed mechanisms of action is reviewed.
Journal ArticleDOI
Selenium and its relationship to cancer: an update.
TL;DR: Even though SeMCYS was shown to be the most effective seleno-compound in the reduction of mammary tumours, it may not be the best choice for reduction of colon tumours because several mechanisms have been proposed on the mechanism whereby Se reduces tumours.
Journal ArticleDOI
Prediagnostic serum selenium and risk of cancer.
Walter C. Willett,J. Steven Morris,Sara L. Pressel,James Taylor,B. Frank Polk,Meir J. Stampfer,Bernard Rosner,Kenneth. Schneider,Curtis G. Hames +8 more
TL;DR: The association between low selenium level and cancer was strongest for gastrointestinal and prostatic cancers and Serum levels of vitamins A and E compounded the effect of low Selenium.
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