Journal ArticleDOI
Release of contractile agents from rat vas deferens by clonidine.
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TLDR
If clonidine is incubated for about 10 min with a nutrient solution containing an isolated rat vas deferens, the resulting solution can contract an isolatedRat uterus, or guinea-pig ileum indicating the involvement of a substance released from the vas.About:
This article is published in Life Sciences.The article was published on 1991-01-01. It has received 10 citations till now. The article focuses on the topics: Vas deferens.read more
Citations
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Journal ArticleDOI
Evidence for participation of nitric oxide in excitatory neurotransmission in rat vas deferens
TL;DR: Results indicate that nitric oxide is involved in excitatory nerve-muscle transmission in vas deferens and cause an inhibition of electrically induced effects in most of the preparations, contrary to the expectations for a precursor of Nitric oxide synthesis.
Journal ArticleDOI
Functional properties of agmatine in rat vas deferens
TL;DR: It is concluded that agmatine has multiple effects on sympathetic neurotransmission in rat vas deferens.
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Decreased noradrenergic and serotonergic reactivity of vas deferens of newborn rats from mothers treated with the serotonin reuptake inhibitor fluoxetine during pregnancy and breast-feeding
TL;DR: It is concluded that, besides the alterations on body weights, changes on noradrenergic and serotonergic mechanisms were observed and persisted in the newborn, at least one month after parturition.
Journal ArticleDOI
Effects of clonidine in the isolated rat testicular capsule.
Edilson Dantas da Silva Júnior,Bruno Palmieri de Souza,Juliano Quintella Dantas Rodrigues,Afonso Caricati-Neto,Aron Jurkiewicz,Neide H. Jurkiewicz +5 more
TL;DR: The results indicate the presence of α2-adrenoceptors in testicular capsule and suggest these receptors may be desensitized by clonidine, causing a decreased potency of noradrenaline.
Journal ArticleDOI
Contractile responses of the rat vas deferens after epithelium removal.
TL;DR: A significant function of the epithelium in the contractility of the rat vas deferens was demonstrated for clonidine, but not for other agonists.
References
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Journal ArticleDOI
Clonidine blocks acute opiate-withdrawal symptoms
TL;DR: The data suggest that opiate withdrawal is due to increased neuronal activity in areas such as the locus coeruleus which are regulated by both alpha-2 adrenergic and opiate receptors.
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Heavy smokers, smoking cessation, and clonidine. Results of a double-blind, randomized trial.
Alexander H. Glassman,Fay Stetner,B. Timothy Walsh,Pamela S. Raizman,Joseph L. Fleiss,Thomas B. Cooper,Lirio S. Covey +6 more
TL;DR: Findings are highly suggestive of an important role of clonidine in smoking cessation, and warrant further studies to establish the long-term efficacy of this drug and to replicate the association between nicotine dependence and depression.
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Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla
TL;DR: Describing binding sites labeled by [3H]p-aminoclonidine in bovine brain membranes prepared from the ventrolateral medulla found that these sites may mediate, in part, the hypotensive action of clonidine and other imidazole compounds in the ventral medulla.
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Pharmacological characterisation of the presynaptic α-adrenoceptor in the rat vas deferens
TL;DR: The results characterise the presynaptic α-adrenoceptors in the rat vas deferens as being of the same type as those present in the rabbit pulmonary artery and rat heart, but different from those located postsynaptically in sympathetically innervated tissues.