Journal ArticleDOI
Reproducibility of atypia of undetermined significance/follicular lesion of undetermined significance category using the bethesda system for reporting thyroid cytology when reviewing slides from different institutions: A study of interobserver variability among cytopathologists.
Vijayalakshmi Padmanabhan,Carrie Marshall,Güliz A. Barkan,Mohiedean Ghofrani,Alice Laser,Idris Tolgay Ocal,Charles D. Sturgis,Rhona J. Souers,Daniel F.I. Kurtycz +8 more
TLDR
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) offers a six‐tiered diagnostic scheme for thyroid Fine Needle Aspiration: Benign, Atypia of Undetermined Significance/Follicular Lesion of Und determined Significant (AUS/FLUS), suspicious for follicular neoplasm, suspicious for malignancy, malignant, and unsatisfactory with an aim to standardize diagnostic criteria.Abstract:
Background The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) offers a six-tiered diagnostic scheme for thyroid Fine Needle Aspiration (FNA): Benign, Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS), suspicious for follicular neoplasm, suspicious for malignancy, malignant, and unsatisfactory with an aim to standardize diagnostic criteria. Reported rate of AUS/FLUS category in the literature has varied from 3% to 20.5%. Methods The aim of this study was to assess interobserver variability among cytopathologists to assess reproducibility of the AUS/FLUS category. Seven cytopathologists brought FNA cases (a mixture of atypical and non-atypical FNA diagnosis) diagnosed using TBSRTC from their respective institutions which were reviewed and diagnosed by the participants. The analysis assessed interobserver variability among 7 cytopathologists and determined characteristics on the slides which were associated with concordance to the institutional diagnosis. Results Seventy eight of 125 (62.4%) benign cases were classified as benign by the reviewers and 26 (21%) were called AUS/FLUS on review. A third of the AUS/FLUS cases were called benign on review and 28.2% were classified as suspicious for neoplasia/malignancy. Roughly a third each of the suspicious for follicular neoplasm/suspicious for malignancy cases were classified as AUS/FLUS. Discussion When pathologists from different institutions shared their slides, concordance was high for specimens with adequate cellularity and those that were clearly benign but thresholds varied for the other indeterminate categories. Most definite categorization of the AUS/FLUS category was seen on review. Diagn. Cytopathol. 2017;45:399-405. © 2017 Wiley Periodicals, Inc.read more
Citations
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Journal ArticleDOI
The incidental thyroid nodule
Sarah B. Fisher,Nancy D. Perrier +1 more
TL;DR: In cases of cytologically indeterminate or discordant nodules, surgical excision (lobectomy) offers a definitive diagnosis, although molecular testing or a reasonable period of observation may be useful as less invasive adjuncts.
Journal ArticleDOI
Northern Italy in the American South: Assessing interobserver reliability within the Milan System for Reporting Salivary Gland Cytopathology.
Johnathan Hollyfield,Siobhan O'Connor,Susan J. Maygarden,Kevin G. Greene,Lori R Scanga,Sherry Tang,Leslie G. Dodd,Sara E. Wobker +7 more
TL;DR: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has been proposed to standardize salivary gland fine‐needle aspiration (FNA) diagnoses as well as the interobserver reliability of the atypia of undetermined significance (AUS) and salivARY gland neoplasm of uncertain malignant potential (SUMP) categories.
Journal ArticleDOI
Paris Interobserver Reproducibility Study (PIRST).
Daniel F.I. Kurtycz,Güliz A. Barkan,Derek M. Pavelec,Dorothy L. Rosenthal,Eva M. Wojcik,Christopher J. VandenBussche,Kala Mangiulli,Matthew T. Olson +7 more
TL;DR: The NHGUC, LGUN, and HGUC were most correlated with diagnostic agreement among observers, and board-certified cytopathologists and specialist cytotechnologists outperformed other certifications.
Journal ArticleDOI
Thyroseq®v2.0 molecular testing: a cost-effective approach for the evaluation of indeterminate thyroid nodules
Ana Marcella Rivas,Aziza Nassar,Jun Zhang,John D. Casler,Ana Maria Chindris,Robert C. Smallridge,Victor Bernet +6 more
TL;DR: The use of ThyroSeq® in the authors' institution is cost effective compared to diagnostic thyroid surgery for the evaluation of Bethesda categories III and IV (SFN) nodules.
Journal ArticleDOI
The Bethesda System for Reporting Thyroid Cytopathology: A Cytohistological Study.
TL;DR: This study substantiates greater reproducibility among pathologists using TBSRTC to arrive at a precise diagnosis with an added advantage of predicting the risk of malignancy which enables the clinician to plan for follow-up or surgery and also the extent of surgery.
References
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Journal ArticleDOI
The Bethesda System for Reporting Thyroid Cytopathology.
Edmund S. Cibas,Syed Z. Ali +1 more
TL;DR: The project participants hope that the adoption of this framework will facilitate communication among cytopathologists, endocrinologists, surgeons, and radiologists; facilitate cytologic-histologic correlation for thyroid diseases; facilitate research into the understanding of Thyroid diseases; and allow easy and reliable sharing of data from different laboratories for national and international collaborative studies.
Journal ArticleDOI
The Bethesda System for Reporting Thyroid Cytopathology
Edmund S. Cibas,Syed Z. Ali +1 more
TL;DR: The conclusions regarding terminology and morphologic criteria from the NCI meeting led to the Bethesda Thyroid Atlas Project and form the framework for The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), a flexible framework for communication and research into thyroid diseases.
Journal ArticleDOI
Fine-Needle Aspiration Biopsy of the Thyroid: An Appraisal
Hossein Gharib,John R. Goellner +1 more
TL;DR: The utility and limitations of fine-needle aspiration biopsy in the evaluation and management of thyroid nodules are examined by reviewing studies reported in the literature from 1982 to 1991 and using 12 years of experience with more than 11 000 biopsies to offer a reasoned approach to the management of nodular thyroid disease.
Journal ArticleDOI
Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference.
Zubair W. Baloch,Virginia A. LiVolsi,Syl L. Asa M.D.,Juan Rosai,Maria J. Merino,Gregory Randolph,Philippe Vielh,Richard M. DeMay,Mary K. Sidawy,William J. Frable +9 more
TL;DR: This document summarizes matters regarding diagnostic terminology/classification scheme for thyroid FNA interpretation and cytomorphologic criteria for the diagnosis of various benign and malignant thyroid lesions.
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Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology
Erik K. Alexander,Giulia C. Kennedy,Zubair W. Baloch,Edmund S. Cibas,Darya Chudova,James C. Diggans,Lyssa Friedman,Richard T. Kloos,Virginia A. LiVolsi,Susan J. Mandel,Stephen S. Raab,Juan Rosai,David L. Steward,P. Sean Walsh,Jonathan I. Wilde,Martha A. Zeiger,Richard B. Lanman,Bryan R. Haugen +17 more