Journal ArticleDOI
Respiratory syncytial virus protects against the subsequent development of ovalbumin‐induced allergic responses by inhibiting Th2‐type γδ T cells
Leiying Zhang,Jing Liu,Enhua Wang,Bing Wang,Sheng Zeng,Jianqi Wu,Yoshinobu Kimura,Beixing Liu +7 more
TLDR
The results described here support the idea of an unknown γδ T cell‐dependent mechanism in the regulation of RSV‐affected, allergen‐induced allergic airway responses.Abstract:
Respiratory syncytial virus (RSV) infection has been hypothesized to be a risk factor for the development of allergy and asthma, but epidemiologic studies in humans still remain inconclusive. The association between RSV infection and allergic diseases may be dependent on an atopic background and previous history of RSV infection. It has been reported that RSV infection before sensitization to an allergen decreased the production of Th2-like cytokines in the lung and the levels of allergen-specific Th2-type antibodies in the serum. However, the underlying mechanisms are largely unknown. In the present study, the role of pulmonary γδ T cells in RSV-affected, allergen-induced airway inflammation was investigated. BALB/c mice were sensitized to or challenged with ovalbumin (OVA) and infected with RSV either before or after the sensitization period. It became clear that sensitization and challenge of mice with OVA induced a large influx of γδ T cells to the lungs. However, prior RSV infection inhibited the infiltration of γδ T cells as well as activated γδ T cells, characterized by expression of CD40L or CD69 molecular in the cell surface. Moreover, prior RSV infection elevated the type 1 cytokine gene expression but suppressed type 2 cytokine expression in the lung γδ T cells. Adoptive transfer of γδ T cells from OVA-sensitized and challenged mice increased airway inflammation, suggesting that γδ T cells may play a proinflammatory role in allergic responses. These results described here support the idea of an unknown γδ T cell-dependent mechanism in the regulation of RSV-affected, allergen-induced allergic airway responses. J. Med. Virol. 85:149–156, 2012. © 2012 Wiley Periodicals, Inc.read more
Citations
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Journal ArticleDOI
γδ T cells and their potential for immunotherapy.
TL;DR: Based on the results of the reported trials, γδ T cells appear to be a promising tool for novel immunotherapies against certain types of diseases.
Journal ArticleDOI
AllergenOnline: A peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity.
Richard E. Goodman,Motohiro Ebisawa,Fatima Ferreira,Hugh A. Sampson,Ronald van Ree,Stefan Vieths,Joseph L. Baumert,Barbara Bohle,Sreedevi Lalithambika,John Wise,Steve L. Taylor +10 more
TL;DR: AllergenOnline provides a useful peer-reviewed tool for identifying the primary potential risks of allergy for GMOs and novel foods based on criteria described by the Codex Alimentarius Commission (2003).
Journal ArticleDOI
Lung-resident γδ T cells and their roles in lung diseases.
Min Cheng,Shilian Hu +1 more
TL;DR: The involvement of γδ T cells in infectious diseases of the lung, including bacterial, viral and fungal infections; lung allergic disease; lung inflammation and fibrosis; and lung cancer is discussed.
Journal ArticleDOI
γδ T Lymphocytes in Asthma: a Complicated Picture.
Michał K. Zarobkiewicz,Ewelina Wawryk-Gawda,Wioleta Kowalska,Mariola Janiszewska,Agnieszka Bojarska-Junak +4 more
TL;DR: In this paper, the authors review the current knowledge about the involvement of γδ T cells in the pathogenesis of asthma and its exacerbations and summarize both the studies performed on human subjects as well as on the murine model of asthma.
Journal ArticleDOI
Respiratory syncytial virus prevents the subsequent development of ovalbumin-induced allergic responses by inhibiting ILC2 via the IL-33/ST2 pathway.
Dandan Wang,Song Bai,Yulin Cui,Na Zhao,Feifei Qi,Jing Liu,Sheng Zeng,Lei Xu,Haiyan Hu,Beixing Liu +9 more
TL;DR: It is demonstrated that previous infection with RSV attenuates OVA-induced airway inflammation by inhibiting the recruitment and Th2 cytokine production of ILC2s via the IL-33/ST2 pathway.
References
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Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography
Eckard Hamelmann,Jürgen Schwarze,Katsuyuki Takeda,A. Oshiba,Gary L. Larsen,Charles G. Irvin,Erwin W. Gelfand +6 more
TL;DR: Measurement of AR to inhaled methacholine by barometric whole-body plethysmography is a valid indicator of airway hyperresponsiveness after allergic sensitization in mice, and it is shown that AR measured as Penh was associated with increased IgE production and eosinophil lung infiltration.
Journal ArticleDOI
Requirement for γδ T Cells in Allergic Airway Inflammation
Claudia Zuany-Amorim,Claude Ruffié,Solomon Haile,B. Boris Vargaftig,Pablo Pereira,Marina Pretolani +5 more
TL;DR: Mice that lacked gammadelta T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration compared with wild-type mice, but responses were restored by administration of IL-4 to g Mohammadelta T cell-deficient mice during the primary immunization.
Journal ArticleDOI
Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization.
Eckard Hamelmann,A. Oshiba,Janette Paluh,Kathleen Bradley,Joan Loader,Terry A. Potter,Gary L. Larsen,Erwin W. Gelfand +7 more
TL;DR: A critical role for CD8+ T cells in the production of IL-5 and the development of altered airway responsiveness after antigen sensitization through the airways is indicated.
Journal ArticleDOI
Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells.
Michael Lahn,Arihiko Kanehiro,Katsuyuki Takeda,Anthony Joetham,Jürgen Schwarze,Gabriele Köhler,Rebecca L. O'Brien,Erwin W. Gelfand,Willi K. Born +8 more
TL;DR: It is demonstrated that γδ T cells can regulate airway function in an αβ T cell-independent manner, identifying them as important cells in pulmonary homeostasis.
Journal ArticleDOI
Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells
Pablo A. González,Carolina Prado,Eduardo Leiva,Leandro J. Carreño,Susan M. Bueno,Claudia A. Riedel,Alexis M. Kalergis +6 more
TL;DR: It is shown that, although RSV infection induces maturation of murine DCs, these cells are rendered unable to activate antigen-specific T cells, suggesting that impairment of immunological synapse could contribute to RSV pathogenesis by evading adaptive immunity and reducing T cell-mediated virus clearance.