Journal ArticleDOI
Responsive polymer systems for controlled delivery of therapeutics
Joseph Kost,Robert Langer +1 more
TLDR
This review focuses on two basic approaches: externally regulated systems (utilizing triggers such as magnetism, ultrasound, temperature and electricity), and self-regulated systems ( utilizing pH-sensitive polymers, enzyme-substrate reactions, competitive binding, and antibody interactions).About:
This article is published in Trends in Biotechnology.The article was published on 1992-01-01. It has received 73 citations till now.read more
Citations
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Journal ArticleDOI
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
Journal ArticleDOI
Mechanisms of polymer degradation and erosion
TL;DR: The most important features of the degradation and erosion of degradable polymers in vitro are discussed in this article, where a brief survey on approaches to polymer degradation and degradation is given.
Journal ArticleDOI
Future perspectives and recent advances in stimuli-responsive materials
TL;DR: It is the goal to emphasize underutilized adaptive behaviors of stimuli-responsive polymers so that novel applications and new generations of smart materials can be realized.
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Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound.
TL;DR: The results of a comprehensive in vivo study of a novel tumor-targeting modality based on the encapsulation of the chemotherapeutic agent within polymeric micelles in combination with a local ultrasonic irradiation of the tumor are reported.
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Receptor and transport properties of imprinted polymer membranes – a review
TL;DR: The nature of selectivity of microporous MIP membranes is discussed and a descriptive model for transport selectivity via specific “gates” is developed, which open a way to the design of supramolecular devices that could perform highly selective functions such as recognition, transformation, transfer, regulation and allow signal and information processing.
References
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Journal ArticleDOI
New methods of drug delivery.
TL;DR: Conventional forms of drug administration generally rely on pills, eye drops, ointments, and intravenous solutions, but a number of novel drug delivery approaches have been developed, which may revolutionize the way many drugs are delivered.
Journal ArticleDOI
Thermally reversible hydrogels: II. Delivery and selective removal of substances from aqueous solutions
TL;DR: Hydrogels have been synthesized which exhibit a lower critical solution temperature (LCST) and which shrink and deswell in aquous solutions when the temperature is raised through their LCST, and how a specific binding ligand may be incorporated into the gel for selective binding (and removal or recovery) of specific solutes in aqueous solutions is shown.
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Thermo-sensitive polymers as on-off switches for drug release
TL;DR: Liberation de l'indomethacine contenue dans le copolymere N-isopropylacrylamide-methacrylate de butyle as discussed by the authors.
Journal ArticleDOI
lontophoretic Devices for Drug Delivery
TL;DR: The design and development of iontophoretic devices are rather simple and the principles of operation and the advantages/disadvantages and clinical implications associated with these devices are outlined in this review.
Journal ArticleDOI
A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin.
Michael Brownlee,Anthony Cerami +1 more
TL;DR: In this article, a stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized, which could have important applications in the therapy of diabetes mellitus.