Journal ArticleDOI
Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys.
Luca Giovannini,Massimiliano Migliori,Biancamaria Longoni,Dipak K. Das,A. A. E. Bertelli,Vincenzo Panichi,C Filippi,Aldo Bertelli +7 more
TLDR
The results suggest that resveratrol reduced the renal ischemia reperfusion injury through a nitric oxide-dependent mechanism.Abstract:
Reactive oxygen species have been implicated in the pathophysiology of renal ischemia reperfusion injury. Antioxidants including polyphenolics have been found to protect renal cells from the cellular injury induced by ischemia and reperfusion. Resveratrol, a stilbene polyphenol found in grapes and red wine, has recently been found to protect isolated rat heart from ischemia reperfusion injury. This study was sought to determine if resveratrol could also protect renal cells from ischemic injury. Male Wistar rats were treated with control, resveratrol (0.23 microg/kg), vehicle used to solubilize resveratrol, and resveratrol plus L-NAME (15 mg/kg body wt), a nitric oxide blocker. Our results demonstrated that resveratrol administration reduced the mortality of ischemic rats from 50% to 10% and renal damage was reduced as indicated by histologic examination and serum creatinine level. The short-term administration of resveratrol also inhibited renal lipid peroxidation induced by ischemia and reperfusion both in cortex and in medulla. Electron paramagnetic resonance detected an increased formation of nitric oxide in the resveratrol-treated kidney that was reduced to the baseline value after treating the rats with L-NAME in addition to resveratrol. The results suggest that resveratrol reduced the renal ischemia reperfusion injury through a nitric oxide-dependent mechanism.read more
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Journal ArticleDOI
Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
TL;DR: A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.
Journal ArticleDOI
Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes
Shweta Rane,Minzhen He,Danish Sayed,Himanshu Vashistha,Ashwani Malhotra,Junichi Sadoshima,Dorothy E. Vatner,Stephen F. Vatner,Maha Abdellatif +8 more
TL;DR: It is reported here that miR-199a is acutely downregulated in cardiac myocytes on a decline in oxygen tension and this reduction is required for the rapid upregulation of its target, hypoxia-inducible factor (Hif)-1α.
Journal ArticleDOI
Resveratrol protects against global cerebral ischemic injury in gerbils.
Qun Wang,Jianfeng Xu,George E. Rottinghaus,Agnes Simonyi,Dennis B. Lubahn,Grace Y. Sun,Albert Y. Sun +6 more
TL;DR: It is demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury.
Journal ArticleDOI
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
TL;DR: The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular reactive oxygen species (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive as discussed by the authors.
Repository
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
TL;DR: It is argued that the role of poorly liganded iron has been rather underappreciated in the past, and that in combination with peroxide and superoxide its activity underpins the behaviour of a great many physiological processes that degrade over time.
References
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Regulation of Bcl-2 Protein Expression during Oxidative Stress in Neuronal and in Endothelial Cells
TL;DR: Interestingly, chronic treatment with clinical concentrations of cyclosporin A led to a significant increase in Bcl-2 expression, while nucleosomes were similar to control level, which suggests that up-regulation of B cl-2 protein by low levels of oxidants may represent a critical factor in cellular adaptation to drug toxicity.