Journal ArticleDOI
Resveratrol protects against global cerebral ischemic injury in gerbils.
Qun Wang,Jianfeng Xu,George E. Rottinghaus,Agnes Simonyi,Dennis B. Lubahn,Grace Y. Sun,Albert Y. Sun +6 more
TLDR
It is demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury.About:
This article is published in Brain Research.The article was published on 2002-12-27. It has received 507 citations till now. The article focuses on the topics: Resveratrol & Ischemia.read more
Citations
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Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
TL;DR: A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.
Journal Article
Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies
Bharat B. Aggarwal,Anjana Bhardwaj,Rishi S. Aggarwal,Navindra P. Seeram,Shishir Shishodia,Yasunari Takada +5 more
TL;DR: In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression.
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Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate
Dario Riccardo Valenzano,Eva Terzibasi,Tyrone Genade,Antonino Cattaneo,Luciano Domenici,Alessandro Cellerino +5 more
TL;DR: It is demonstrated that food supplementation with resveratrol prolongs lifespan and retards the expression of age-dependent traits in a short-lived vertebrate.
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Resveratrol stimulates AMP kinase activity in neurons.
TL;DR: It is shown that resveratrol activated AMPK in Neuro2a cells and primary neurons in vitro as well as in the brain, suggesting that neuronal activation of AMPK by resver atrol could affect neuronal energy homeostasis and contribute to the neuroprotective effects of resverAtrol.
Biochemical Changes throughout Grape Berry Development and Fruit and Wine Quality
Carlos Conde,Paulo Silva,Natacha Fontes,Alberto Carlos Pires Dias,Rui Manuel Tavares,Maria João Sousa,Alice Agasse,Serge Delrot,Hernâni Gerós +8 more
TL;DR: In this article, the authors studied the key control points in grape ripening and concluded that optimal grape maturity is essential for wine quality, but is difficult to assess because it is under multifactorial control, involving grapevine cultivar variety and environmental parameters such as soil, temperature, exposure to sun, and hormonal regulation.
References
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Reactive astrocytes: cellular and molecular cues to biological function
TL;DR: Reactive astrocytes should be considered a key element, like neurons, of a dynamic environment, thus forming with neurons a functional unit involved in homeostasis, plasticity and neurotransmission.
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Biological effects of resveratrol.
TL;DR: Resveratrol has been shown to modulate the metabolism of lipids, and to inhibit the oxidation of low-density lipoproteins and the aggregation of platelets, and may play a role in the prevention of human cardiovascular diseases.
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Reactive oxygen radicals in signaling and damage in the ischemic brain.
TL;DR: Transgenic or knockout mice with cell- or site-specific prooxidant and antioxidant enzymes provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury.
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Selective vulnerability of the hippocampus in brain ischemia.
TL;DR: *Department of Neurophysiology, Institute of Physiology, Medical Faculty, Ruhr-Universitlt Bochum, and MRC Anatomical Neuropharmacology Unit, _ Department of Pha-rmacology, University of Oxford, Oxford, U.K.R.G.
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Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis
TL;DR: Delayed death of the CA1 pyramidal neurons after brief ischemia is not necrotic but apoptotic, suggesting that cathepsin B- immunopositive lysosomes increasing in the neurons after ischemic insult are mostly autolysosomes.