Journal ArticleDOI
Resveratrol effects in oral cancer cells: a comprehensive review
Tamires Cunha Almeida,Glenda Nicioli da Silva,Daniel Vitor de Souza,Andréa Cristina de Moraes Malinverni,Odair Aguiar,Debora Estadella,Daniel Araki Ribeiro +6 more
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TLDR
In this article, a review of different action mechanisms of resveratrol related in the in vitro and in vivo studies using models of oral cancer is presented, where the authors discuss the different action mechanism of reserveratrol in both vitro and vivo studies.Abstract:
Oral cancer is a very common tumor worldwide with high incidence and mortality. The treatment of oral cancer involves surgery, radio- and chemotherapy; however, high failure rates and toxicity are noticed. Thus, the search of new drugs aiming a more effective treatment is welcomed. Natural products present chemopreventive and anti-cancer effects. Resveratrol is a naturally occurring antioxidant that contains several health benefits, including anti-inflammatory and antiproliferative activities. This review discusses the different action mechanisms of resveratrol related in the in vitro and in vivo studies using models of oral cancer.read more
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Metformin inhibits the tumor-promoting effect of low-dose resveratrol, and enhances the anti-tumor activity of high-dose resveratrol by increasing its reducibility in triple negative breast cancer
Ting Fang Cheng,Cheng Wang,Qianqian Lu,Yuliang Cao,Weiwei Yu,Wenzhen Li,Ben Liu,Xue Gao,Junhong Lü,Xiaohong Pan +9 more
TL;DR: Wang et al. as mentioned in this paper investigated the anti-TNBC mechanism of resveratrol under a mimic hypoxic tumor microenvironment and explored a method of combining metformin to improve the therapeutic effect.
Journal ArticleDOI
Effects and mechanisms of resveratrol for prevention and management of cancers: An updated review.
Silan Wu,Ruoxuan Xiong,Si-Yu Huang,Dan Zhou,Adila Saimaiti,Cai-Ning Zhao,Ao Shang,Yunjian Zhang,Ren-You Gan,Hua-Bin Li +9 more
TL;DR: The effects and mechanisms of resveratrol on different cancers are summarized and crude extract containing resver atrol is developed into functional food, dietary supplements or auxiliary agents for prevention and management of cancers.
Journal ArticleDOI
Identification of therapeutically potential targets and their ligands for the treatment of OSCC
Pratima Kumari,Sugandh Kumar,Madhusmita Sethy,Shyamlal Bhue,Bineet Kumar Mohanta,Anshuman Dixit +5 more
TL;DR: In this article , drug-specific sensitivity-related prognostic biomarkers (BOP1, CCNA2, CKS2, PLAU, and SERPINE1) were identified using gene expression, Cox proportional hazards regression, and machine learning in OSCC.
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Research Progress on Natural Products' Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels
TL;DR: Based on the classification of chemical structures, Chen et al. as discussed by the authors discussed the natural product components' therapeutic effects on atrial fibrillation by regulating ion channels, connexins, and expression of related genes.
References
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TRIM67 Activates p53 to Suppress Colorectal Cancer Initiation and Progression.
Shiyan Wang,Yanquan Zhang,Junzhe Huang,Chi Chun Wong,Jianning Zhai,Chuangen Li,Guifeng Wei,Liuyang Zhao,Guoping Wang,Hong Wei,Zengren Zhao,Jun Yu +11 more
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Resveratrol chemosensitizes adriamycin‐resistant breast cancer cells by modulating miR‐122‐5p
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Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells.
Feng-Yan Lin,Yi-Hsien Hsieh,Shun-Fa Yang,Chang-Tai Chen,Chih-Hsin Tang,Chih-Hsin Tang,Ming-Yung Chou,Yi-Ting Chuang,Chiao-Wen Lin,Mu-Kuan Chen +9 more
TL;DR: Resveratrol inhibited MMP-9 expression and oral cancer cell metastasis by downregulating JNK1/2 and ERK1/ 2 signals pathways and, thus, exerts beneficial effects in chemoprevention.