Open AccessJournal Article
Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity.
TLDR
A transplantable, murine reticulum cell sarcoma is described which exhibits the cytologic, adherence, and phagocytic properties of macrophages and mediate antibody-dependent cellular immunity as assayed by release of radioactivity from 51Cr-labeled erythrocytes.Abstract:
A transplantable, murine reticulum cell sarcoma is described which exhibits the cytologic, adherence, and phagocytic properties of macrophages. It forms specific rosettes with erythrocytes in the presence of the corresponding anti-serum. The ascites cells mediate antibody-dependent cellular immunity as assayed by release of radioactivity from 51Cr-labeled erythrocytes. The contribution of contaminating host cells in the cytotoxic reaction was ruled out by growing the tumor in F1 mice and removing the host cells by anti-H2 serum and complement. The tumor cells have receptors for IgG2a and IgG2b immunoglobulins. The availability of a pure population of effector cells in the immune system allows study of the biochemical processes pursuant to lysis of foreign cells.read more
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F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Jonathan M. Austyn,Siamon Gordon +1 more
TL;DR: Immunoprecipitation experiments demonstrated that the antigen F4/80 is part of a component of Mr 160000 which is synthesized by the MΦ and, at least in part, exposed on the cell surface.
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Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.
TL;DR: Once inside a host cell, the infecting Listeria and their progeny can spread from cell to cell by remaining intracellular and thus bypass the humoral immune system of the organism.
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Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.
TL;DR: The ability of the hybridoma IgG to inhibit mouse FcRII was independent of the major histocompatibility complex and the monoclonal 2.4G2 IgG antigenic determinant was not present on rat, guinea pig, rabbit, or human F cR-bearing cells.
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Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.
TL;DR: It is shown that endothelial cells have the potential to metabolically modify the LDL molecule, generating a form that is more rapidly degraded by macrophages and that is recognized by the macrophage receptor for acetylated LDL.
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Role of hemolysin for the intracellular growth of Listeria monocytogenes.
TL;DR: Hemolytic-positive revertants were selected after passage of the hly- mutants through monolayers of J774 cells, and in each case, the hemolytic revertants possessed the 58-kD polypeptide, were capable of intracellular growth in tissue culture monolayer and were virulent for mice.