Journal ArticleDOI
Retinal ischemia: mechanisms of damage and potential therapeutic strategies.
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TLDR
Given the increasing understanding of the events involved in ischemic neuronal injury, it is hoped that clinically effective treatments for retinal ischemia will soon be available.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2004-01-01. It has received 886 citations till now. The article focuses on the topics: Ischemic cascade & Neuroprotection.read more
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Müller Cells in the Healthy and Diseased Retina
Andreas Bringmann,Thomas Pannicke,Jens Grosche,Mike Francke,Peter Wiedemann,Serguei N. Skatchkov,Neville N. Osborne,Andreas Reichenbach +7 more
TL;DR: A proper understanding of the gliotic responses of Müller cells in the diseased retina, and of their protective vs. detrimental effects, is essential for the development of efficient therapeutic strategies that use and stimulate the neuron-supportive/protective-and prevent the destructive-mechanisms of gliosis.
Journal ArticleDOI
Reperfusion injury and reactive oxygen species: The evolution of a concept.
D. Neil Granger,Peter R. Kvietys +1 more
TL;DR: The possibility that multiple ROS sources contribute to reperfusion injury in most tissues is supported by evidence demonstrating that redox-signaling enables ROS produced by one enzymatic source to activate and enhance ROS production by a second source.
Journal ArticleDOI
The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina.
TL;DR: The hypothesis that omega-3 (o-3) long-chain polyunsaturated fatty acids (LCPUFAs) exhibit cytoprotective and cytotherapeutic actions contributing to a number of anti-angiogenic and neuroprotective mechanisms within the retina was proposed in this paper.
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Integrated Systems Approach to Study the Role of Omega-3 Long-Chain Polyunsaturated Fatty Acids in Health and Disease of the Retina
John Paul SanGiovanni,C. M. Aderman,Cecilia V. Rojas,Traci E Clemons,E. Y. Chew,Ricardo Uauy,Dennis R. Hoffman,Lois E.H. Smith +7 more
TL;DR: The hypothesis that omega-3 (omega-3) long-chain polyunsaturated fatty acids (LCPUFAs) exhibit cytoprotective and cytotherapeutic actions contributing to a number of anti-angiogenic and neuroprotective mechanisms within the retina is advanced.
Journal ArticleDOI
The progress in understanding and treatment of diabetic retinopathy
Alan W. Stitt,Tim M. Curtis,Mei Chen,Reinhold J. Medina,Gareth J. McKay,Alicia J. Jenkins,Tom A. Gardiner,Timothy J. Lyons,Hans-Peter Hammes,Rafael Simó,Noemi Lois +10 more
TL;DR: It is emphasised that although there have been significant advances, there is still a pressing need for a better understanding basic mechanisms enable development of reliable and robust means to identify patients at highest risk, and to intervene effectively before vision loss occurs.
References
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Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
TL;DR: The multiple anginal episodes that often precede myocardial infarction in man may delay cell death after coronary occlusion, and thereby allow for greater salvage of myocardium through reperfusion therapy, which is proposed to protect the heart from a subsequent sustained ischemic insult.
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Ischemic Cell Death in Brain Neurons
TL;DR: A major unifying thread of the review is a consideration of how the changes occurring during and after ischemia conspire to produce damaging levels of free radicals and peroxynitrite to activate calpain and other Ca(2+)-driven processes that are damaging, and to initiate the apoptotic process.
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Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
TL;DR: It is suggested that the large increase in the content of extracellular glutamate and aspartate in the hippocampus induced by the ischemic period may be one of the causal factors in the damage to certain neurons observed after ischemia.
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Excitatory amino acids as a final common pathway for neurologic disorders.
TL;DR: In many neurologic disorders, injury to neurons may be caused at least in part by overstimulation of receptors for excitatory amino acids, including glutamate and aspartate.
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Thresholds in cerebral ischemia - the ischemic penumbra.
TL;DR: Recent evidence indicates that immediate failure of basic functions such as synaptic transmission, ion pumping and energy metabolism in the ischemic brain, is critically dependent on residual blood flow, and that these functions fail at certain critical flow thresholds.