Journal ArticleDOI
Review: allergic contact stomatitis.
TLDR
Allergic contact stomatitis (ACS) is an oral mucosal immuno-inflammatory disorder variably characterized by erythematous plaques, vesiculation, ulceration, and hyperkeratosis and by pain, burning sensation, or itchiness as mentioned in this paper.Abstract:
Allergic contact stomatitis (ACS) is an oral mucosal immunoinflammatory disorder variably characterized clinically by erythematous plaques, vesiculation, ulceration, and/or hyperkeratosis and by pain, burning sensation, or itchiness. ACS is brought about by a T cell-mediated, delayed hypersensitivity immune reaction generated by a second or subsequent contact exposure of an allergen with the oral mucosa, in a genetically susceptible, sensitized subject. Lichenoid contact reaction is a variant of ACS brought about by direct contact with the oral mucosa of certain metals in dental restorations. The features of ACS are neither clinically nor histopathologically specific, so the diagnosis is usually presumptive and can only be confirmed by resolution of the inflammation after withdrawal or removal of the suspected causative allergen. When ACS is suspected but an allergen cannot be identified, patch testing is necessary. In persistent cases, topical corticosteroids are the treatment of choice, but for severe and extensive lesions, systemic corticosteroid and systemic antihistamines may be indicated. In this short review, we highlight the clinical, immunologic, and histopathological features of ACS, and provide some guidelines for diagnosis and management.read more
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Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis
TL;DR: The relationship between vitamin D, oral immunity and periodontal disease is discussed and the rationale for using vitamin D supplementation to help maintainperiodontal health and as an adjunct to standard periodontAL treatment is reviewed.
Journal ArticleDOI
Hypersensitivity reaction of the gingiva to chlorhexidine: case report and literature review.
Elli Anna Kotsailidi,Eleni-Marina Kalogirou,Dimitrios Michelogiannakis,Dimitrios Vlachodimitropoulos,Konstantinos I. Tosios +4 more
TL;DR: Clinicians should be aware that oral hygiene products containing even low concentrations of chlorhexidine might induce hypersensitivity reactions, and be aware of the risks and benefits to patients with intraoral manifestations of hypers sensitivity reactions associated with chlor hexidine-containing oral hygiene Products.
Journal ArticleDOI
Triggers of oral lichen planus flares and the potential role of trigger avoidance in disease management.
TL;DR: Trigger identification and avoidance can play a potentially effective role in the management of OLP, and of those who actively avoided triggers, 89% reported an improvement in symptoms and 70% reported a decrease in the frequency of flares.
Journal ArticleDOI
Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method
Kunihiko Yamashita,Hiroshi Miyazaki,Shinsuke Shinoda,Saori Hagiwara,Hirohito Takahashi,Hiroshi Itagaki +5 more
TL;DR: Four of the 10 natural organic chemicals tested had a skin sensitization potential, with shikonin producing serious reaction even at a very low concentration.
Journal ArticleDOI
Inflammatory, Reactive, and Hypersensitivity Lesions Potentially Due to Metal Nanoparticles from Dental Implants and Supported Restorations: An Umbrella Review
Federica di Spirito,Roberto Lo Giudice,Massimo Amato,Mariagiovanna Di Palo,Francesco D’Ambrosio,Alessandra Amato,Stefano Martina +6 more
TL;DR: In this paper , the authors assess the prevalence of cases diagnosed with lesions potentially due to Titanium (alloy) and other metal nanoparticles released from dental implants and implant-supported restorations, characterizing lesions' macroscopic, imaging and microscopic features.
References
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Journal ArticleDOI
The development of allergic inflammation
TL;DR: It is important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reaction.
Journal ArticleDOI
Early immune events in the induction of allergic contact dermatitis
TL;DR: This Review examines how innate immune cells in the skin, including mast cells and dendritic cells, cooperate with each other and with T cells and keratinocytes to initiate and drive early responses to contact allergens.
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Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.
Anne Dudeck,Jan Dudeck,Julia Scholten,Anke Petzold,Sangeetha Surianarayanan,Anja Köhler,Katrin Peschke,David Vöhringer,Claudia Waskow,Thomas Krieg,Werner Müller,Ari Waisman,Karin Hartmann,Matthias Gunzer,Axel Roers +14 more
TL;DR: It is demonstrated that mast cells are essential promoters of contact hypersensitivity, thereby highlighting their potential to promote immune responses to antigens entering via the skin.
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Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients.
Alberto Sicilia,Susana Cuesta,Gerardo Coma,Ignacio Arregui,Cristina Guisasola,Eduardo Ruiz,Antonio Maestro +6 more
TL;DR: Ti allergy can be detected in dental implant patients, even though its estimated prevalence is low (0.6%), and a significantly higher risk of positive allergic reaction was found in patients showing post-op allergy compatible response (ACRG), in which cases allergy tests could be recommended.
Journal Article
Cutaneous Drug Reactions
TL;DR: Evidence that viral infection is an important predisposing factor for the development of cutaneous drug reactions upon drug administration is described, and the current knowledge of the type and mechanisms of cutaneously drug reactions to several categories of drugs is assessed.