Review of Natural Compounds for Potential Skin Cancer Treatment
Tawona N. Chinembiri,Lissinda H. Du Plessis,Minja Gerber,Josias H. Hamman,Jeanetta du Plessis +4 more
TLDR
This review aims at providing an overview of anti-cancer compounds, derived from natural sources, that are currently used in cancer chemotherapies, or that have been reported to show anti-melanoma, or anti-skin cancer activities.Abstract:
Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. Various treatments for malignant melanoma are available, but due to the development of multi-drug resistance, current or emerging chemotherapies have a relatively low success rates. This emphasizes the importance of discovering new compounds that are both safe and effective against melanoma. In vitro testing of melanoma cell lines and murine melanoma models offers the opportunity for identifying mechanisms of action of plant derived compounds and extracts. Common anti-melanoma effects of natural compounds include potentiating apoptosis, inhibiting cell proliferation and inhibiting metastasis. There are different mechanisms and pathways responsible for anti-melanoma actions of medicinal compounds such as promotion of caspase activity, inhibition of angiogenesis and inhibition of the effects of tumor promoting proteins such as PI3-K, Bcl-2, STAT3 and MMPs. This review thus aims at providing an overview of anti-cancer compounds, derived from natural sources, that are currently used in cancer chemotherapies, or that have been reported to show anti-melanoma, or anti-skin cancer activities. Phytochemicals that are discussed in this review include flavonoids, carotenoids, terpenoids, vitamins, sulforaphane, some polyphenols and crude plant extracts.read more
Citations
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Cellular and molecular mechanisms of curcumin in prevention and treatment of disease
Sita Sharan Patel,Ashish Acharya,Ratan Singh Ray,Ritesh Agrawal,Ramsaneh Raghuwanshi,Priyal Jain +5 more
TL;DR: Curcumin has a potential to prevent and/or manage various diseases due to its anti-inflammatory, anti-oxidant and anti-apoptotic properties with an excellent safety profile.
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Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer.
Elena Talero,Sofía García-Mauriño,Javier Ávila-Román,Azahara Rodríguez-Luna,Antonio Montero Alcaide,Virginia Motilva +5 more
TL;DR: Main mechanisms of actions of these compounds in the chemoprevention of these cancers include suppression of cell proliferation, induction of apoptosis, stimulation of antimetastatic and antiangiogenic responses and increased antioxidant and anti-inflammatory activity.
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Production of carotenoids by microalgae: achievements and challenges
TL;DR: The factors inducing carotenoid accumulation in microalgae are outlined, the knowledge acquired on the metabolic pathways responsible for their biosynthesis, and the recent achievements in the genetic engineering of this pathway are outlined.
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Roesmary and cancer prevention: Preclinical perspectives
TL;DR: The results suggested that the different molecular targets modulated by rosemary and its active constituents are useful indicators of success in clinical cancer chemo-prevention trials.
References
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TL;DR: Some of the recent advances in flavonoid research are reviewed and the role of anthocyanins and flavones in providing stable blue flower colours in the angiosperms is outlined.
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Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease.
Charles H. Hennekens,Julie E. Buring,JoAnn E. Manson,Meir J. Stampfer,Bernard Rosner,Nancy R. Cook,Charlene Belanger,Frances LaMotte,John Michael Gaziano,Paul M. Ridker,Walter C. Willett,Richard Peto +11 more
TL;DR: In this trial among healthy men, 12 years of supplementation with beta carotene produced neither benefit nor harm in terms of the incidence of malignant neoplasms, cardiovascular disease, or death from all causes.
Journal ArticleDOI
Natural products: a continuing source of novel drug leads.
Gordon M. Cragg,David J. Newman +1 more
TL;DR: This review traces natural products drug discovery, outlining important drugs from natural sources that revolutionized treatment of serious diseases and effective drug development depends on multidisciplinary collaborations.
Journal ArticleDOI
Plants as a source of anti-cancer agents.
Gordon M. Cragg,David J. Newman +1 more
TL;DR: A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest.