Risk factors for chronic kidney disease: an update
TLDR
Determination of serum creatinine levels and urinalysis in patients with chronic kidney disease risk will usually be sufficient for initial screening, and this should be able to identify individuals with increased risk of renal disease.About:
This article is published in Kidney International.The article was published on 2013-12-01 and is currently open access. It has received 386 citations till now. The article focuses on the topics: Kidney disease & Renal replacement therapy.read more
Citations
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Journal ArticleDOI
Chronic Kidney Disease Diagnosis and Management: A Review
TL;DR: Optimal management of CKD includes cardiovascular risk reduction, treatment of albuminuria, avoidance of potential nephrotoxins, and adjustments to drug dosing (eg, many antibiotics and oral hypoglycemic agents).
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Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease.
TL;DR: The role of oxidative stress and inflammation in renal impairment is shown, with a particular emphasis on its influence on the most common disturbances that accompany CKD.
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Healthy Dietary Patterns and Incidence of CKD: A Meta-Analysis of Cohort Studies.
Katrina E Bach,Jaimon T Kelly,Suetonia C. Palmer,Saman Khalesi,Giovanni F.M. Strippoli,Giovanni F.M. Strippoli,Katrina L. Campbell +6 more
TL;DR: A healthy dietary pattern may prevent CKD and albuminuria and the evidence certainty was moderate for CKD incidence and low for eGFR decline and incidentalbuminuria.
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Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis
Verónica Miguel,Jessica Tituaña,J. Ignacio Herrero,Laura Herrero,Dolors Serra,Paula Cuevas,Coral Barbas,Diego Rodríguez Puyol,Laura Marquez-Exposito,Marta Ruiz-Ortega,Carolina Castillo,Xin Sheng,Katalin Susztak,Miguel Ruiz-Canela,Jordi Salas-Salvadó,Miguel A. Martinez Gonzalez,Sagrario Ortega,Ricardo Alan Verdú Ramos,Santiago Lamas +18 more
TL;DR: In this article, a conditional transgenic mouse model with overexpression of the fatty acid shuttling enzyme carnitine palmitoyl-transferase 1A (CPT1A) was generated to determine whether gain of function in FAO (FAO-GOF) could protect from fibrosis.
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Kidney-based in vitro models for drug-induced toxicity testing
TL;DR: An overview of drug-induced injuries to the kidney is provided, details on relevant and translational biomarkers, and advances in 3D cultures of human renal cells, including organoids and kidney-on-a-chip platforms are provided.
References
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Prevalence of Chronic Kidney Disease in the United States
Josef Coresh,Elizabeth Selvin,Lesley A. Stevens,Jane Manzi,John W. Kusek,Paul W. Eggers,Frederick Van Lente,Andrew S. Levey +7 more
TL;DR: The prevalence of CKD in the United States in 1999-2004 is higher than it was in 1988-1994 and this increase is partly explained by the increasing prevalence of diabetes and hypertension and raises concerns about future increased incidence of kidney failure and other complications.
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Blood Pressure and End-Stage Renal Disease in Men
Michael J. Klag,Paul K. Whelton,Bryan L. Randall,James D. Neaton,Frederick L. Brancati,Charles E. Ford,Neil B. Shulman,Jeremiah Stamler +7 more
TL;DR: Elevations of blood pressure are a strong independent risk factor for end-stage renal disease; interventions to prevent the disease need to emphasize the prevention and control of both high-normal and high blood pressure.
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Prognostic value of serum creatinine and effect of treatment of hypertension on renal function. Results from the hypertension detection and follow-up program. The Hypertension Detection and Follow-up Program Cooperative Group.
Neil B. Shulman,Charles E. Ford,W D Hall,M D Blaufox,D Simon,Herbert G. Langford,Kenneth A. Schneider +6 more
TL;DR: The slightly lower rate of development of hypercreatininemia and the higher rate of improvement in stepped-care compared with referred-care participants is consistent with the belief that aggressive treatment of hypertension may reduce renal damage and the associated increased risk of death.
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Multiple loci associated with indices of renal function and chronic kidney disease
Anna Köttgen,Nicole L. Glazer,Abbas Dehghan,Shih-Jen Hwang,Ronit Katz,Man Li,Qiong Yang,Vilmundur Gudnason,Lenore J. Launer,Tamara B. Harris,Albert V. Smith,Dan E. Arking,Brad C. Astor,Eric Boerwinkle,Georg Ehret,Georg Ehret,Ingo Ruczinski,Robert B. Scharpf,Yii-Der Ida Chen,Ian H. de Boer,Talin Haritunians,Thomas Lumley,Mark J. Sarnak,David S. Siscovick,Emelia J. Benjamin,Daniel Levy,Ashish Upadhyay,Yurii S. Aulchenko,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Cornelia M. van Duijn,Daniel I. Chasman,Guillaume Paré,Paul M. Ridker,W. H. Linda Kao,Jacqueline C.M. Witteman,Josef Coresh,Michael G. Shlipak,Caroline S. Fox,Caroline S. Fox +40 more
TL;DR: These findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease.
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Obesity and Risk for Chronic Renal Failure
Elisabeth Ejerblad,C. Michael Fored,Per Lindblad,Jon P. Fryzek,Joseph K. McLaughlin,Olof Nyrén +5 more
TL;DR: Obesity seems to be an important-and potentially preventable-risk factor for CRF, and the strongest association was with diabetic nephropathy, but two- to three-fold risk elevations were observed for all major subtypes of CRF.