Morgan E. Grams

TL;DR: This study estimated levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs) by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017 and explored the relationship between development and risk exposure.

TL;DR: Optimal management of CKD includes cardiovascular risk reduction, treatment of albuminuria, avoidance of potential nephrotoxins, and adjustments to drug dosing (eg, many antibiotics and oral hypoglycemic agents).

TL;DR: Proton pump inhibitor use was associated with incident CKD in unadjusted analysis and in analysis adjusted for demographic, socioeconomic, and clinical variables and future research should evaluate whether limiting PPI use reduces the incidence of CKD.

TL;DR: Kidney failure risk equations developed in a Canadian population showed high discrimination and adequate calibration when validated in 31 multinational cohorts, but the original risk equations overestimated risk in some non-North American cohorts.

TL;DR: Both sexes face increased risk of all-cause mortality, cardiovascular mortality, and end stage renal disease with lower estimated glomerular filtration rates and higher albuminuria.