Journal ArticleDOI
RNA and protein synthesis required for entry of cells into mitosis and during the mitotic cycle.
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TLDR
Cells in the latter part of the mitotic cycle already contain a 1–3 hr supply of ribosomes which can be utilized for the syntheses involved in preparing cells for division, suggesting that new protein molecules must be synthesized within a 30–60 min period prior to metaphase for division to occur.About:
This article is published in Experimental Cell Research.The article was published on 1967-04-01. It has received 53 citations till now. The article focuses on the topics: Cell division & Mitosis.read more
Citations
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Journal ArticleDOI
The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes
Katherine I. Swenson,Katherine I. Swenson,Kevin M. Farrell,Kevin M. Farrell,Joan V. Ruderman,Joan V. Ruderman +5 more
TL;DR: Findings indicate that the rise in cyclin A plays a direct and natural role in driving cells into M phase.
Journal ArticleDOI
Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells
Robert Schlegel,Arthur B. Pardee +1 more
TL;DR: It is suggested that caffeine induces the translation or stabilizes the protein product (or products) of mitosis-related RNA that accumulates in S-phase cells when DNA replication is suppressed.
Journal ArticleDOI
Regulation of thymidine kinase synthesis in human cells.
TL;DR: A detailed study of the time at which TdR kinase synthesis is terminated indicates that enzyme synthesis ends at about the time cells begin mitosis rather than at the time DNA synthesis is complete, indicating that replication of the total complement of DNA is required.
Journal ArticleDOI
Initiation and growth of microtubules from mitotic centers in lysed mammalian cells.
J A Snyder,J R McIntosh +1 more
TL;DR: The ability of the centriole to initiate microtubule assembly is a time- dependent process-a ripening effect takes place between prophase and late prometaphase, and Ripening is expressed by an increase in the number and length of tubules found associated with the Centriolar region.
Book ChapterDOI
The control of cell division in the ocular lens.
TL;DR: In this article, the control of cell division in the ocular lens is discussed and the nature of the effects of environmental factors on the controlling of the cell division process is discussed.
References
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Journal ArticleDOI
Crystalline desoxyribonuclease: i. isolation and general properties spectrophotometric method for the measurement of desoxyribonuclease activity
TL;DR: A crystalline enzyme capable of digesting thymus nucleic acid (desoxyribonucleic acid) has been isolated from fresh beef pancreas and the spectrophotometric measurement of the rate of increase in the light absorption can be conveniently used as a general method for estimating desoxy ribonuclease activity.
Journal ArticleDOI
Selective effects of actinomycin D on the intracellular distribution of RNA synthesis in tissue culture cells
TL;DR: The intracellular pattern of RNA synthesis in tissue culture cells is altered in a well defined way by treatment with low concentrations of actinomycin D, consistent with the hypothesis that the stable elements of ribosomal RNA are derived from the nucleolar region of the nucleus.
Journal ArticleDOI
Quantitative cytochemical studies on interphase growth: I. Determination of DNA, RNA and mass content of age determined mouse fibroblasts in vitro and of intercellular variation in generation time
D. Killander,Anders Zetterberg +1 more
TL;DR: The importance of such a critical mass was discussed with regard to maintenance of the size homogeneity of the cell population, intercellular variations in generation times and the “trigger” mechanism for mitosis.
Journal ArticleDOI
A quantitative cytochemical investigation of the relationship between cell mass and initiation of DNA synthesis in mouse fibroblasts in vitro.
D. Killander,Anders Zetterberg +1 more
TL;DR: The mass of cells entering interphase after cell division, initial mass (mo), and the cell mass at the stage of initiation of DNA synthesis (mG1) were determined in 21 populations of mouse fibroblasts in vitro (L-cells) which exhibited different mo values.
Journal ArticleDOI
Life Cycle Analysis of Mammalian Cells: III. The Inhibition of Division in Chinese Hamster Cells by Puromycin and Actinomycin
TL;DR: Analysis of the effects of actinomycin and puromycin on the G(2) and mitotic parts of the life cycle in Chinese hamster ovary cells grown in suspension and synchronized by thymidine treatment has been carried out.
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Life Cycle Analysis of Mammalian Cells: III. The Inhibition of Division in Chinese Hamster Cells by Puromycin and Actinomycin
Quantitative cytochemical studies on interphase growth: I. Determination of DNA, RNA and mass content of age determined mouse fibroblasts in vitro and of intercellular variation in generation time
D. Killander,Anders Zetterberg +1 more