Journal ArticleDOI
Role of opioidergic and serotonergic mechanisms in cough and antitussives.
TLDR
The results indicate that the antitussive effects of opioids are mediated predominantly by mu- and kappa-opioid receptors, and suggest that sigma sites may be involved in the antitussedive mechanism of non-narcotic antitussives.About:
This article is published in Pulmonary Pharmacology.The article was published on 1996-10-01. It has received 94 citations till now. The article focuses on the topics: Antitussive Agent & Noscapine.read more
Citations
More filters
Journal ArticleDOI
Pharmacokinetics of opioids in liver disease.
TL;DR: Although glucuronidation is thought to be less affected in liver cirrhosis, the clearance of morphine was found to be decreased and oral bioavailability increased, and the disposition of a few opioids, such as fentanyl, sufent anil and remifentanil, appears to be unaffected in liver disease.
Journal ArticleDOI
Practical metal-free C(sp(3))-H functionalization: construction of structurally diverse α-substituted N-benzyl and N-allyl carbamates.
TL;DR: The metal-free reaction has an excellent functional-group tolerance, and displays a broad scope with respect to both N-carbamates and nucleophile partners (a variety of organoboranes and CH compounds).
Journal ArticleDOI
Cough and paradoxical vocal fold motion.
Kenneth W. Altman,C. Blake Simpson,Milan R. Amin,Mona M. Abaza,R. O. N. Balkissoon,Roy R. Casiano +5 more
TL;DR: Gastroesophageal reflux disease, vagal neuropathy, and paradoxical vocal fold motion are additional causes of chronic cough and disordered breathing that need to be considered, in the absence of obvious laryngotracheal and/or rhinologic pathology.
Journal ArticleDOI
The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications.
TL;DR: The intriguing story of this family of nontoxic alkaloids, from noscapine's purification from opium at the turn of the 19th century in Paris to the recent torrent of rationally designed analogs with tremendous anticancer potential is discussed.
Journal ArticleDOI
Pediatric palliative care: use of opioids for the management of pain.
TL;DR: Detailed pediatric pharmacokinetic and pharmacodynamic data for opioids, their indications and contraindications, as well as dose-administration regimens that include practical strategies for opioid switching and dose reduction are presented.