Journal ArticleDOI
ROS implication in a new antitumor strategy based on non-thermal plasma.
Marc Vandamme,Eric Robert,Stéphanie Lerondel,Vanessa Sarron,Delphine Ries,Sébastien Dozias,Julien Sobilo,David Gosset,Claudine Kieda,Brigitte Legrain,Jean-Michel Pouvesle,Alain Le Pape,Alain Le Pape +12 more
TLDR
The potential of NTP to generate ROS renders this strategy particularly promising in the context of tumor treatment, as well as in vitro and in vivo experiments.Abstract:
Non-thermal plasma (NTP) is generated by ionizing neutral gas molecules/atoms leading to a highly reactive gas at ambient temperature containing excited molecules, reactive species and generating transient electric fields. Given its potential to interact with tissue or cells without a significant temperature increase, NTP appears as a promising approach for the treatment of various diseases including cancer. The aim of our study was to evaluate the interest of NTP both in vitro and in vivo. To this end, we evaluated the antitumor activity of NTP in vitro on two human cancer cell lines (glioblastoma U87MG and colorectal carcinoma HCT-116). Our data showed that NTP generated a large amount of reactive oxygen species (ROS), leading to the formation of DNA damages. This resulted in a multiphase cell cycle arrest and a subsequent apoptosis induction. In addition, in vivo experiments on U87MG bearing mice showed that NTP induced a reduction of bioluminescence and tumor volume as compared to nontreated mice. An induction of apoptosis was also observed together with an accumulation of cells in S phase of the cell cycle suggesting an arrest of tumor proliferation. In conclusion, we demonstrated here that the potential of NTP to generate ROS renders this strategy particularly promising in the context of tumor treatment.read more
Citations
More filters
Journal ArticleDOI
The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology
TL;DR: The importance of ROS and RNS to plant biology has been relatively little appreciated in the plasma biomedicine community, but it appears that there are opportunities for useful applications of plasmas in this area as well.
Journal ArticleDOI
Reactive species in non-equilibrium atmospheric-pressure plasmas: Generation, transport, and biological effects
Xinpei Lu,Xinpei Lu,George V. Naidis,Mounir Laroussi,Stephan Reuter,David B. Graves,Ken Ostrikov +6 more
TL;DR: In this paper, the most important mechanisms of generation and transport of the key species in the plasmas of atmospheric-pressure plasma jets and other non-equilibrium atmospheric pressure plasms are introduced and examined from the viewpoint of their applications in plasma hygiene and medicine and other relevant fields.
Journal ArticleDOI
Plasmas for medicine
TL;DR: The aim of the new research field of plasma medicine is the exploitation of a much more differentiated interaction of specific plasma components with specific structural as well as functional elements or functionalities of living cells.
Journal ArticleDOI
Cold atmospheric plasma in cancer therapya)
Michael Keidar,Alex Shashurin,Olga Volotskova,Mary Ann Stepp,Priya Srinivasan,Anthony D. Sandler,Barry Trink +6 more
TL;DR: Study indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway and the cancer cells are more susceptible to the effects of CAP.
Journal ArticleDOI
Cold atmospheric plasma, a novel promising anti-cancer treatment modality.
TL;DR: This review provides a comprehensive introduction of the basics of CAP, state of the art research in this field, the primary challenges, and future directions to cancer biologists.
References
More filters
Book
Radiobiology for the radiologist
Eric J. Hall,Amato J. Giaccia +1 more
TL;DR: Radiobiology for the radiologist, Radiobiology in general, Radiology for radiologists as mentioned in this paper, Radiology in the field of radiology, radiology for radiology.
Journal ArticleDOI
Applied Plasma Medicine
Gregory Fridman,Gary Friedman,Alexander Gutsol,Anatoly B. Shekhter,Victor N. Vasilets,Alexander Fridman +5 more
TL;DR: Non-equilibrium plasmas will be shown to be non-destructive to tissue, safe, and effective in inactivation of various parasites and foreign organisms.
Journal ArticleDOI
Plasma medicine: an introductory review
Michael G. Kong,Gmw Gerrit Kroesen,Gregor E. Morfill,Tetyana Nosenko,Tetsuji Shimizu,van J Jan Dijk,Julia L. Zimmermann +6 more
TL;DR: This introductory review on plasma health care is intended to provide the interested reader with a summary of the current status of this emerging field, its scope, and its broad interdisciplinary approach, ranging from plasma physics, chemistry and technology, to microbiology, biochemistry, biophysics, medicine and hygiene.
Journal ArticleDOI
Low Temperature Plasma-Based Sterilization: Overview and State-of-the-Art
TL;DR: Low temperature, high pressure, non-equilibrium plAsmas are now routinely used in several material processing applications, and in some cases are competing with low pressure plasmas in areas where these have historically been dominant.
Journal ArticleDOI
Gas discharge plasmas and their applications
TL;DR: An overview of gas discharge plasmas can be found in this paper, where the most important applications of these and related plasmmas are discussed, as well as their working principles.