Journal ArticleDOI
Royal Jelly Protects Against Ultraviolet B–Induced Photoaging in Human Skin Fibroblasts via Enhancing Collagen Production
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TLDR
Royal jelly may potentially protect the skin from UVB-induced photoaging by enhancing collagen production by measuring the 10-HDA content of RJ by high-performance liquid chromatography and testing the effects of RJ on UVb-induced skin photoaging in normal human dermal fibroblasts.Abstract:
Royal jelly (RJ) is a honeybee product containing proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. As its principal unsaturated fatty acid, RJ contains 10-hydroxy-2-decenoic acid (10-HDA), which may have antitumor and antibacterial activity and a capacity to stimulate collagen production. RJ has attracted interest in various parts of the world for its pharmacological properties. However, the effects of RJ on ultraviolet (UV)-induced photoaging of the skin have not been reported. In this study we measured the 10-HDA content of RJ by high-performance liquid chromatography and tested the effects of RJ on UVB-induced skin photoaging in normal human dermal fibroblasts. The effects of RJ and 10-HDA on UVB-induced photoaging were tested by measuring procollagen type I, transforming growth factor (TGF)-β1, and matrix metalloproteinase (MMP)-1 after UVB irradiation. The RJ contained about 0.211% 10-HDA. The UVB-irradiated human skin fibroblasts treated with RJ and 10-HDA had increa...read more
Citations
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Journal ArticleDOI
Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits.
TL;DR: The effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed and the modes of actions of these products have been illustrated for purposes of better understanding.
Journal ArticleDOI
Therapeutic Properties of Bioactive Compounds from Different Honeybee Products.
TL;DR: This review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.
Journal ArticleDOI
New Insights into the Biological and Pharmaceutical Properties of Royal Jelly
TL;DR: The recent research advances on the main bioactive compounds of RJ are highlighted, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits.
Journal ArticleDOI
Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans.
TL;DR: RJ and its protein and lipid ingredients have the potential to extend lifespan in various creatures and prevent senescence of human tissues in cell cultures and pave the way to inventing specific RJ anti-aging drugs.
Journal ArticleDOI
Bee-derived antibacterial peptide, defensin-1, promotes wound re-epithelialisation in vitro and in vivo.
Marcela Bucekova,Martin Sojka,Ivana Valachova,Simona Martinotti,Elia Ranzato,Zoltan Szep,Viktor Majtan,Jaroslav Klaudiny,Juraj Majtan,Juraj Majtan +9 more
TL;DR: In this paper, the authors demonstrate that keratinocytes are responsible for the elevated production of matrix metalloproteinase-9 (MMP-9) after incubation with a water extract of Royal Jelly (RJ).
References
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Journal ArticleDOI
Mechanisms of photoaging and chronological skin aging
Gary J. Fisher,Sewon Kang,James Varani,Zsuzsanna Bata-Csorgo,Yinsheng Wan,Subhash C. Datta,John J. Voorhees +6 more
TL;DR: This article reviews the current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time and reveals that chronological aging and photoaging share fundamental molecular pathways.
Journal ArticleDOI
Skin ageing and its treatment
TL;DR: The influence of the sun in extrinsic skin ageing, as well as its role in potentially altering the normal course of intrinsic (also known as natural or cellular) ageing, is discussed.
Journal ArticleDOI
Photoaging of human skin.
TL;DR: Understanding of photoaging has increased significantly and has led to new prophylactic and therapeutic strategies aimed at the prevention and repair of the detrimental effects of chronic sun‐exposure on the skin.
Journal ArticleDOI
An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-β
TL;DR: It is demonstrated that overexpression of c-jun in co-transfection experiments with COL1A2 promoter/CAT constructs blocks the TGF-β response, further implicating AP-1 in the regulation of COL 1A2 gene expression.
Journal ArticleDOI
c-Jun–dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid
Gary J. Fisher,Subhash C. Datta,Zeng Quan Wang,Xiao Yan Li,Taihao Quan,Jin Ho Chung,Sewon Kang,John J. Voorhees +7 more
TL;DR: It is reported here that a single exposure to UV irradiation causes significant loss of procollagen synthesis in human skin, and pretreatment of skin with all-trans retinoic acid protects against both of these deleterious effects and may thereby retard premature skin aging.