Journal ArticleDOI
S-adenosylmethionine and Catechol-O-methyltransferase in Schizophrenia
TLDR
There is a significant correlation between blood COMT activity and SAMe concentration, which suggests that some schizophrenics may methylate biogenic amines more actively than others.Abstract:
The authors examined the hypothesis of disordered transmethylation in schizophrenia by comparing S-adenosylmethionine (SAMe) concentration and cathechol-O-methyltransferase (COMT) activities in venous blood of schizophrenic and nonschizophrenic patients. While they did not find a difference in blood SAMe concentration between the groups, they did find a significant correlation between blood COMT activity and SAMe concentration. This suggests that some schizophrenics may methylate biogenic amines more actively than others.read more
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Journal ArticleDOI
The Dopamine Hypothesis of Schizophrenia: A Review*
Journal ArticleDOI
Bipolar I Disorder and Schizophrenia: A 440–Single-Nucleotide Polymorphism Screen of 64 Candidate Genes among Ashkenazi Jewish Case-Parent Trios
M. Daniele Fallin,Virginia K. Lasseter,Dimitrios Avramopoulos,Kristin K. Nicodemus,Paula S. Wolyniec,John A. McGrath,Gary Steel,Gerald Nestadt,Kung Yee Liang,Richard L. Huganir,David Valle,Ann E. Pulver +11 more
TL;DR: A single-nucleotide polymorphism genotyping screen of 64 candidate genes chosen on the basis of previous linkage or of association and/or biological relevance provides further support for shared genetic susceptibility between schizophrenia and bipolar disorders that involve glutamate-signaling pathways.
Journal ArticleDOI
Role of S-adenosyl-l-methionine in the treatment of depression: a review of the evidence
David Mischoulon,Maurizio Fava +1 more
TL;DR: Overall, SAMe appears to be safe and effective in the treatment of depression, but more research is needed to determine optimal doses and to clarify SAMe's place in the psychopharmacologic armamentarium.
Journal ArticleDOI
S-adenosylmethionine levels in psychiatric and neurological disorders: a review.
T Bottiglieri,K Hyland +1 more
TL;DR: Intravenous or oral administration of SAMe thus represents a possible treatment for these neurological and metabolic disorders.
Journal ArticleDOI
Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele.
Dimitrios Avramopoulos,Nicholas C. Stefanis,I. Hantoumi,Nikolaos Smyrnis,Nikolaos Smyrnis,Ioannis Evdokimidis,Costas N. Stefanis +6 more
TL;DR: It is concluded that the COMT genotype for the functional Val158Met polymorphism is correlated to self-reported schizotypy in healthy males, adding to the list of evidence that COMT or a nearby gene in linkage disequilibrium is involved in the pathogenesis of the disease.