Journal ArticleDOI
Safety and tolerability of antipsychotic agents in neurodevelopmental disorders: a systematic review.
Felice Iasevoli,Annarita Barone,Elisabetta F. Buonaguro,Licia Vellucci,Andrea de Bartolomeis +4 more
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TLDR
Antipsychotic agents used in NDDs were found to mainly cause the following side effects: metabolic disturbances; sedation; prolactin increases and sexual dysfunctions; neurological and behavioral disorders; cardiological and hematological side effects.Abstract:
Neurodevelopmental disorders (NDDs) are a group of complex and heterogeneous disorders, caused by the disruption of normal brain development. Antipsychotic agents are frequently used in these disor...read more
Citations
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Safety and Efficacy of Aripiprazole in the Long-Term Maintenance Treatment of Pediatric Patients with Irritability Associated with Autistic Disorder
TL;DR: In this article, the efficacy and safety of aripiprazole versus placebo in preventing relapse of irritability symptoms associated with autistic disorder in pediatric patients was evaluated in a randomized, double-blind, randomized, placebo-controlled, relapse-prevention trial.
Pharmacological interventions for challenging behaviour in children with intellectual disabilities: a systematic review and meta-analysis (vol 15, pg 303, 2015)
TL;DR: Antipsychotic medications appear to be effective for reducing challenging behaviour in the short-term among children with intellectual disabilities, but they carry a risk of significant side effects.
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Clozapine’s multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia
TL;DR: In this article , the role and specific relevance of clozapine's multimodal actions are examined, dissecting those mechanisms that under a translational perspective could shed light on molecular targets worth to be considered for further innovative antipsychotic development.
Journal ArticleDOI
Mental health problems in children with intellectual disability.
TL;DR: In this paper , the authors discuss the prevalence of mental health problems, interventions to address these, and issues of access to treatment and services, and discuss four directions for addressing the mental health inequity in intellectual disability.
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Cariprazine alleviates core behavioral deficits in the prenatal valproic acid exposure model of autism spectrum disorder
Viktor Román,Nika Adham,Andrew G. Foley,Lynsey Hanratty,Bence Farkas,Balázs Lendvai,Bela Kiss +6 more
TL;DR: In this paper, the effects of cariprazine, compared with risperidone and aripiprazole, in the rat prenatal valporic acid (VPA) exposure model on behavioral endpoints representing the core and associated symptoms of ASD were investigated.
References
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Journal ArticleDOI
Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014
Jon Baio,Lisa D. Wiggins,Deborah Christensen,Matthew J. Maenner,Julie L. Daniels,Zachary Warren,Margaret Kurzius-Spencer,Walter Zahorodny,Cordelia Robinson Rosenberg,Tiffany White,Maureen S. Durkin,Pamela Imm,Loizos Nikolaou,Loizos Nikolaou,Marshalyn Yeargin-Allsopp,Li-Ching Lee,Rebecca A. Harrington,Maya Lopez,Robert T. Fitzgerald,P Amy Hewitt,Sydney Pettygrove,John N. Constantino,Alison Vehorn,Josephine Shenouda,Jennifer Hall-Lande,Kim Van Naarden Braun,Nicole F. Dowling +26 more
TL;DR: This report provides updated ASD prevalence estimates for children aged 8 years during the 2014 surveillance year, on the basis of DSM-IV-TR criteria, and describes characteristics of the population of children with ASD.
Journal ArticleDOI
Childhood body-mass index and the risk of coronary heart disease in adulthood
TL;DR: It is found that higher BMI during this period of childhood is associated with an increased risk of any, non-fatal and fatal heart disease in adulthood.
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Risperidone in Children with Autism and Serious Behavioral Problems
James T. McCracken,James J. McGough,Bhavik Shah,Pegeen Cronin,Daniel Hong,Michael G. Aman,L. Eugene Arnold,Ronald L. Lindsay,Patricia L. Nash,Jill A. Hollway,Christopher J. McDougle,David J. Posey,Naomi B. Swiezy,Arlene E. Kohn,Lawrence Scahill,Andrés Martin,Kathleen Koenig,Fred R. Volkmar,Deirdre H. Carroll,Allison Lancor,Allison Lancor,Elaine Tierney,Jaswinder K. Ghuman,N. González,Marco A. Grados,Benedetto Vitiello,Louise Ritz,Mark Davies,James Robinson,Donald J. McMahon +29 more
TL;DR: Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder and the benefit was maintained at six months.
Journal ArticleDOI
International Consensus Study of Antipsychotic Dosing
TL;DR: In the absence of adequate prospective, randomized drug-drug comparisons, the present findings provide broad, international, expert consensus-based recommendations for most clinically employed antipsychotic drugs that can support clinical practice, trial design, and interpretation of comparative antipsychotics trials.
Journal ArticleDOI
Predicting adult obesity from childhood obesity: a systematic review and meta‐analysis
TL;DR: Investigating the ability of simple measures of childhood obesity such as body mass index (BMI) to predict future obesity in adolescence and adulthood found that obese children and adolescents were around five times more likely to be obese in adulthood than those who were not obese.