SARS-CoV-2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time-course study - potential challenge for vaccines and therapies.
Stefanie Weber,Christina M. Ramirez,Barbara Weiser,Harold Burger,Walter Doerfler,Walter Doerfler +5 more
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In this paper, the authors examined >µ383,500 complete SARS-CoV-2 nucleotide sequences in GISAID (Global Initiative of Sharing All Influenza Data) with sampling dates extending until April 05, 2021.Abstract:
Scientists and the public were alarmed at the first large viral variant of SARS-CoV-2 reported in December 2020. We have followed the time course of emerging viral mutants and variants during the SARS-CoV-2 pandemic in ten countries on four continents. We examined > 383,500 complete SARS-CoV-2 nucleotide sequences in GISAID (Global Initiative of Sharing All Influenza Data) with sampling dates extending until April 05, 2021. These sequences originated from ten different countries: United Kingdom, South Africa, Brazil, United States, India, Russia, France, Spain, Germany, and China. Among the 77 to 100 novel mutations, some previously reported mutations waned and some of them increased in prevalence over time. VUI2012/01 (B.1.1.7) and 501Y.V2 (B.1.351), the so-called UK and South Africa variants, respectively, and two variants from Brazil, 484K.V2, now called P.1 and P.2, increased in prevalence. Despite lockdowns, worldwide active replication in genetically and socio-economically diverse populations facilitated selection of new mutations. The data on mutant and variant SARS-CoV-2 strains provided here comprise a global resource for easy access to the myriad mutations and variants detected to date globally. Rapidly evolving new variant and mutant strains might give rise to escape variants, capable of limiting the efficacy of vaccines, therapies, and diagnostic tests.read more
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US Severe Acute Respiratory Syndrome Coronavirus 2 Epsilon Variant: Highly Transmissible but With an Adjusted Muted Host T-Cell Response
Jasmine T. Plummer,Deisy Contreras,Wenjuan Zhang,Aleksandra Binek,Ruan Zhang,Felipe Segato Dezem,Stephanie Chen,Brian D Davis,J. Sincuir Martinez,Aleksandr Stotland,Simion Kreimer,Elias Makhoul,Saleh Heneidi,Celeste Eno,Bongha Shin,Anders H. Berg,S. Cheng,Stanley C. Jordan,Eric Vail,Jennifer E. Van Eyk,Margie Morgan +20 more
TL;DR: While the epsilon SARS-CoV-2 variant is more infectious, by altering viral processing, it is shown that patients with COVID-19 have adapted their innate immune response to this fitter variant.
Journal ArticleDOI
The roles of inactivated vaccines in older patients with infection of Delta variant in Nanjing, China
Xiaochun Song,Xueli Zhou,Jingquan Cheng,Wen-Hao Zhang,Xiaobo Chen,Huiji Xu,Shuai Nie,Jingjing Xiao,Fang Sun,Chang Shu,Jiu-Dong Chen,Yan Tang,Liang Wang,Xin-Pei Sun,Jia-Kui Sun,Ping Feng,Qiankun Shi +16 more
TL;DR: The inactivated COVID-19 vaccines were effective in improving the clinical severity of older patients with infection of Delta variant.
Journal ArticleDOI
OUP accepted manuscript
TL;DR: In this article , the epsilon versus non-epsilicon variants were investigated using a multi-omics approach including cellular response assays and paired cell and host transcriptomic and proteomic profiling.
Journal ArticleDOI
USA SARS-CoV-2 Epsilon Variant: Though Highly Transmissible has an Adjusted Muted Host T-Cell Response.
Jasmine T. Plummer,Deisy Contreras,Wenjuan Zhang,Aleksandra Binek,Ruan Zhang,Felipe Segato Dezem,Stephanie Chen,Brian D Davis,J. Sincuir Martinez,Aleksandr Stotland,Simion Kreimer,Elias Makhoul,Saleh Heneidi,Celeste Eno,Bo Gyeong Shin,Anders H. Berg,S. Cheng,Stanley C. Jordan,Eric Vail,Jennifer E. Van Eyk,Margie Morgan +20 more
TL;DR: While the epsilon variant is more infectious via altering viral processing, it is demonstrated that COVID-19 patients have adapted their innate immune response to this fitter variant and a protective T-cell response molecular signature is generated in both vaccinated and unvaccinated patients.
Journal ArticleDOI
Antisense oligonucleotides targeting ORF1b block replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Sophie Dhorne-Pollet,Chris Fitzpatrick,Bruno Da Costa,C. Martin Bourgon,Jean-François Eléouët,Nicolas Meunier,Verónica A. Burzio,Bernard Delmas,Eric Barrey +8 more
TL;DR: Results show that anti-ORF1b ASO can specifically reduce SARS-CoV-2 genome replication in vitro in two different cell infection models, presenting proof-of concept of antisense oligonucleotide technology as a promising therapeutic strategy for COVID-19.
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