Geographical Distribution of Genetic Variants and Lineages of SARS-CoV-2 in Chile
Andrés E. Castillo,Bárbara Parra,Paz Tapia,Jaime Lagos,Loredana Arata,Alejandra Acevedo,Winston Andrade,Gabriel Leal,Carolina Tambley,Patricia Bustos,Rodrigo Fasce,Jorge Fernández +11 more
TLDR
This work presents the occurrence of genetic variants and lineages of SARS-CoV-2 in Chile during March to April 2020 and revealed a predominance of variant D614G like in Europe and the USA and the major presence of lineage B.Abstract:
The pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide public health concern. First confined in China and then disseminated widely across Europe and America, SARS-CoV-2 has impacted and moved the scientific community around the world to working in a fast and coordinated way to collect all possible information about this virus and generate new strategies and protocols to try to stop the infection. During March 2020, more than 16,000 full viral genomes have been shared in public databases that allow the construction of genetic landscapes for tracking and monitoring the viral advances over time and study the genomic variations present in geographic regions. In this work, we present the occurrence of genetic variants and lineages of SARS-CoV-2 in Chile during March to April 2020. Complete genome analysis of 141 viral samples from different regions of Chile revealed a predominance of variant D614G like in Europe and the USA and the major presence of lineage B.1. These findings could help take control measures due to the similarity of the viral variants present in Chile, compared with other countries, and monitor the dynamic change of virus variants in the country.read more
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References
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Journal ArticleDOI
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
Journal ArticleDOI
A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology.
Andrew Rambaut,Edward C. Holmes,Áine O'Toole,Verity Hill,John T. McCrone,Christopher Ruis,Louis du Plessis,Oliver G. Pybus +7 more
TL;DR: A rational and dynamic virus nomenclature that uses a phylogenetic framework to identify those lineages that contribute most to active spread and is designed to provide a real-time bird’s-eye view of the diversity of the hundreds of thousands of genome sequences collected worldwide.
Journal ArticleDOI
Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China.
An Pan,Li Liu,Chaolong Wang,Huan Guo,Xingjie Hao,Qi Wang,Jiao Huang,Na He,Hongjie Yu,Xihong Lin,Sheng Wei,Tangchun Wu +11 more
TL;DR: A series of multifaceted public health interventions was temporally associated with improved control of the COVID-19 outbreak in Wuhan, China, and may inform public health policy in other countries and regions.
Journal ArticleDOI
The positive impact of lockdown in Wuhan on containing the COVID-19 outbreak in China
Hien Lau,Veria Khosrawipour,Piotr Kocbach,Agata Mikolajczyk,Justyna Schubert,Jacek Bania,Tanja Khosrawipour +6 more
TL;DR: A significantly decreased growth rate and increased doubling time of cases was observed, which is most likely due to Chinese lockdown measures, which seem to have a potential to slow down the spread of COVID-19.
Journal ArticleDOI
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant.
Maria Pachetti,Maria Pachetti,Bruna Marini,Francesca Benedetti,Fabiola Giudici,Elisabetta Mauro,Paola Storici,Claudio Masciovecchio,Silvia Angeletti,Massimo Ciccozzi,Robert C. Gallo,Robert C. Gallo,Davide Zella,Davide Zella,Rudy Ippodrino +14 more
TL;DR: The findings suggest that the virus is evolving and European, North American and Asian strains might coexist, each of them characterized by a different mutation pattern.
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