Journal ArticleDOI
Scale-up of high shear mixer-granulator based on discrete element analysis
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TLDR
In this paper, a scale-up method based on the kinematic and dynamic similarities of particle behavior, motion of particles in a commercial high shear mixer-granulator with different vessel sizes (2 to 112 l) were simulated using a three-dimensional discrete element method (DEM) and the effects of vessel size on the internal particle flow and the particle collision energy were analyzed.About:
This article is published in Powder Technology.The article was published on 2013-02-01. It has received 67 citations till now. The article focuses on the topics: Impeller & Discrete element method.read more
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Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production - A critical review
TL;DR: Modelling and supporting measurement tools for the high shear wet granulation (HSWG) process are reviewed, and the twin-screw granulator as a device for continuous HSWG is focused on and a set of open research questions are identified.
Journal ArticleDOI
Developments in the tools for the investigation of mixing in particulate systems – A review
An-Ni Huang,Hsiu-Po Kuo +1 more
TL;DR: In this paper, a review of tools for the investigation of mixing in particulate systems is presented, where the authors present guidelines for the selections of particle mixers and predictions of the mixture quality after mixing operations.
Journal ArticleDOI
A comprehensive review on process and engineering aspects of pharmaceutical wet granulation
TL;DR: In this paper, a review of various aspects of pharmaceutical granulation like technologies, characterization tools, process control, modelling and simulation, kinetics and scale up have been thoroughly analysed and discussed in terms of development trends and future challenges and prospects.
Segregation of binary mixtures of particles in a bladed mixer
Abstract: This paper presents a numerical study of the flow and segregation of particles over flat blades in a vertical cylindrical mixer by means of a modified discrete element method. Simulations are conducted using a binary mixture of spheres, where the blade's rotating speed, particle size, volume fraction and particle density are the variables considered. Similar flow features are found for all the cases considered: particles rise to form a heap in front of a blade and then either flow downward on the bed surface over the blade or to the base of the heap to rejoin the flow toward the blade, and there is a recirculating zone in front of the blade. However, different types of mixing behaviour can be observed. Particles with large size or light density are mainly in the top layer of the mixing bed, while small and heavy particles remain in the bottom of the mixing bed and in front of the blades. The segregation pattern resulting from size difference is not the same as that resulting from density difference. The force evolution in these two binary systems also differs, although at the initial stage large/light particles always receive a relatively larger vertical force than small/heavy particles, leading to segregation that can be maintained at the later stage. Decreasing the size or density difference promotes the mixing performance. Changing the blade speed affects the mixing kinetics but not the mixing quality.
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Evaluation of particle density effect for mixing behavior in a rotating drum mixer by DEM simulation
TL;DR: The mixing behavior of particles in a rotating drum mixer (RDM) was analyzed by experiment and Distinct Element Method (DEM) simulation in order to discuss the effect of particle density as mentioned in this paper.
References
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Journal Article
Discrete numerical model for granular assemblies.
Peter Cundall,Otto D. L. Strack +1 more
TL;DR: The distinct element method as mentioned in this paper is a numerical model capable of describing the mechanical behavior of assemblies of discs and spheres and is based on the use of an explicit numerical scheme in which the interaction of the particles is monitored contact by contact and the motion of the objects modelled particle by particle.
Journal ArticleDOI
A discrete numerical model for granular assemblies
Peter Cundall,Otto D. L. Strack +1 more
TL;DR: The distinct element method as mentioned in this paper is a numerical model capable of describing the mechanical behavior of assemblies of discs and spheres and is based on the use of an explicit numerical scheme in which the interaction of the particles is monitored contact by contact and the motion of the objects modelled particle by particle.
Journal ArticleDOI
Rolling friction in the dynamic simulation of sandpile formation
TL;DR: In this article, a rolling friction model is proposed to avoid arbitrary treatments or unnecessary assumptions, and its validity is confirmed by the good agreement between the simulated and experimental results under comparable conditions, which suggest that the angle of repose increases significantly with the rolling friction coefficient and decreases with particle size.
Journal ArticleDOI
Critical parameters and limiting conditions in binder granulation of fine powders
TL;DR: In this paper, the authors present a general theoretical and practical framework of binder granulation that takes an agglomeration process from binder selection and testing to granule formation, growth and consolidation.
Journal ArticleDOI
Process control and scale-up of pharmaceutical wet granulation processes: a review.
A. Faure,Peter York,Ray C. Rowe +2 more
TL;DR: For wet granulation in high-shear mixers, specific methods based on the liquid saturation and the consistency of the wet mass are described and engineering techniques based on particle size population balance modelling are under development for both fluid bed and high- shear granulation.