Open AccessJournal Article
Scrapie in sheep and goats.
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This article is published in Frontiers of Biology in China.The article was published on 1976-01-01 and is currently open access. It has received 264 citations till now. The article focuses on the topics: Scrapie.read more
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Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier
TL;DR: The BSE agent has retained its identity when passaged through a range of species and the 'donor' species has little specific influence on disease characteristics in mice, adding to evidence for an agent-specific informational molecule.
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PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie
TL;DR: Genotype analysis showed that dimorphisms in codons 136 and 171 of the ovine PrP gene correlated with control of disease incidence and modulation of incubation time, and the functional effects of these domains of PrP were shown to alternate depending on the isolate of infecting agent.
Journal ArticleDOI
Natural Infection of Suffolk Sheep with Scrapie Virus
TL;DR: The early appearance of virus in tonsil, retropharyngeal and mesenteric-portal lymph nodes, and intestine suggests that primary infection occurs by way of the alimentary tract, either prenatally from virus in amniotic fluid or postnatallyFrom virus in a contaminated environment.
Journal ArticleDOI
The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis.
TL;DR: The present study confirms that scrapie strains carry information which is independent of the host but nevertheless suggests that host PrP protein interacts with this information to regulate the progression of the disease.
Journal ArticleDOI
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes.
Michael R. Scott,Darlene Groth,Dallas Foster,Marilyn Torchia,Shu-Lian Yang,Stephen J. DeArmond,Stanley B. Prusiner +6 more
TL;DR: These findings provide genetic evidence for homophilic interactions between PrPSc in the inoculum and PrPc synthesized by the host.
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