Journal ArticleDOI
Selective mono- and difluorination of enolates
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TLDR
In this paper, the selective transformation of enolates into mono-and difluorinated carbonyl compounds can be performed in a one-pot procedure using N-F-sultam 1.About:
This article is published in Tetrahedron Letters.The article was published on 1991-04-08. It has received 68 citations till now. The article focuses on the topics: Haloketone & Ketone.read more
Citations
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Journal ArticleDOI
Electrophilic NF Fluorinating Agents.
Journal ArticleDOI
Methods for the synthesis of gem-difluoromethylene compounds
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Simple Branched Sulfur–Olefins as Chiral Ligands for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Highly Enantioselective Construction of Tetrasubstituted Carbon Stereocenters
TL;DR: This work has reported the first example of applying a sulfur-olefin ligand in catalytic asymmetric addition of imines in Rh-catalyzed asymmetric arylations of cyclic ketimines.
Journal ArticleDOI
Enantioselective Access to Spirocyclic Sultams by Chiral Cp-x-Rhodium(III)-Catalyzed Annulations
Manh V. Pham,Nicolai Cramer +1 more
TL;DR: The use of rhodium(III) complexes equipped with a suitable atropchiral cyclopentadienyl ligand, in conjunction with a carboxylic acid additive, enables an enantioselective and high yielding access to such spirocyclic sultams.
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Dihaloiodoarenes: α,α-dihalogenation of phenylacetate derivatives.
TL;DR: A hypervalent iodine reagent-based α-carbonyl dihalogenation reaction is reported, which proceeds rapidly and chemoselectively to the desired gem-difunctionalized products in good to excellent yield.
References
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Journal ArticleDOI
Power- and structure-variable fluorinating agents. The N-fluoropyridinium salt system
TL;DR: The N-fluoropyridinium salt system as discussed by the authors provides a new system of fluorinating agents by which a wide range of nucleophilic substrates differing in reactivity can be fluorinated due to the varying degree of the fluorinating power and also selectively through structural alteration.
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New fluorinating reagents - I. The first enantioselective fluorination reaction
Edmond Differding,Robert W. Lang +1 more
TL;DR: In this article, optically pure N-fluoro sultams (−)-3 and (+)-5 are shown to have enantioselective fluorinating reagents and unprecedented enantiomeric excesses up to 70% are observed when various prochiral metal enolates are fluorinated by using these new reagents.
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New fluorinating reagents. Part II. Preparation and Synthetic Application of a Saccharin Derived N‐Fluorosultam
Edmond Differding,Robert W. Lang +1 more
TL;DR: In this paper, the synthesis of the new saccharin derived N-fluorosultam 1 was described, and a comparative study with commercially available Nfluorosulfonamides showed 1 to be a superior fluorinating reagent for the synthesis α-fluorocarbonyl compounds.
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Preparation of α-fluoroaldehydes and α-fluoroketones using dilute fluorine
TL;DR: Fluorination of silyl enol ethers with 5% F2 in N2 at −78°C in Freon 11 results in the formation of α-fluoroketones and αfluoroaldehydes as mentioned in this paper.
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