Journal ArticleDOI
Selective synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzimidazoles in water at ambient temperature
TLDR
In this article, a highly selective synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzimidazoles from the reaction of o-phenylenediamines and aromatic aldehydes in the presence of silica sulfuric acid is reported.About:
This article is published in Tetrahedron Letters.The article was published on 2006-04-10. It has received 147 citations till now. The article focuses on the topics: Aryl & Benzimidazole.read more
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Synthesis of 1,2-disubstituted benzimidazoles, 2-substituted benzimidazoles and 2-substituted benzothiazoles in SDS micelles
TL;DR: In this article, a practical and convenient synthetic method has been developed for the facile synthesis of 1,2-disubstituted benzimidazoles, 2-substitized benzimidsazoles and 2 -substitution of benzothiazoles.
Journal ArticleDOI
Sulfonic acid-functionalized mesoporous silica (SBA-Pr-SO3H) as solid acid catalyst in organic reactions
TL;DR: In this article, a review of the catalytic activity of sulfonic acid-functionalized SBA-15 has been performed and it has been shown that the SBA can be easily removed from the reaction mixture by simple filtration, recovered and reused without significant loss of activity.
Journal ArticleDOI
l-Proline catalyzed selective synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles ☆
TL;DR: In this article, the synthesis of 2-aryl-1-arylmethyl-1 H -benzimidazoles from a wide range of substituted o -phenylenediamines and aldehydes under mild conditions using chloroform as a solvent at ambient temperature.
Journal ArticleDOI
Water mediated chemoselective synthesis of 1,2-disubstituted benzimidazoles using o-phenylenediamine and the extended synthesis of quinoxalines
TL;DR: In this paper, water was used as the reaction medium for the one-pot synthesis of 1,2-disubstituted benzimidazoles in a room temperature viatrimethylsilyl chloride-based reaction.
Journal ArticleDOI
Developments Towards Regioselective Synthesis of 1,2‐Disubstituted Benzimidazoles
TL;DR: Several methods to assemble benzimidazoles play an important role in several areas and particularly as drug discovery targets are reviewed, from the classical approaches to the more recently developed metal-catalyzed intramolecular amination process, the cascade arylamination/condensation reaction and polymer-supported benzimdazole assembly under microwave conditions.
References
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The chemistry of heterocyclic compounds
TL;DR: In this article, it was shown that one of the most common types of known quantities of phenyl phenyl is phenyl oxide (POP) oxide, which is a phenyl-oxyoxy phenyl (PE)-oxyoxyphenyl) that can be obtained from phenyl compounds.
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“On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension
TL;DR: This workFloat their problematic reactions on water and to send observations of success or failure to us at onwater@scripps.edu for public dissemination with attribution.
Journal ArticleDOI
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
Ben E. Evans,Kenneth E. Rittle,Mark G. Bock,Robert M. DiPardo,Roger M. Freidinger,W. L. Whitter,George F. Lundell,Daniel F. Veber,Paul S. Anderson,Raymond S.L. Chang,Victor J. Lotti,D. J. Cerino,Tsing-Bau Chen,Paul J. Kling,K. A. Kunkel,James P. Springer,J. Hirshfield +16 more
TL;DR: 3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described, and the method of development of these compounds is discussed in terms of its relevance to the general problem of drug discovery.
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Water: From Clusters to the Bulk
TL;DR: The exploration of structural and binding properties of small water complexes provides a key for understanding bulk water in its liquid and solid phase and for understanding solvation phenomena.