Journal ArticleDOI
Selenium, glutathione peroxidase (GSH-Px) and lipid peroxidation products before and after selenium supplementation.
Berenice C. Wilke,Michel Vidailhet,Allain Favier,Catherine Guillemin,Véronique Ducros,J. Arnaud,Marie Jeanne Richard +6 more
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TLDR
In this paper, the authors have studied 15 treated phenylketonuric (PKU) children and 30 control children and observed significantly lower plasma and erythrocyte selenium, as well as significantly lower (P less than 0.0005) plasma and glutathione peroxidase activities (GSH-Px) in PKU children than in controls.About:
This article is published in Clinica Chimica Acta.The article was published on 1992-04-30. It has received 75 citations till now. The article focuses on the topics: Selenium deficiency & Glutathione peroxidase.read more
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Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant
TL;DR: The antioxidant role of nutritional supplementation of selenium in the management of major chronic metabolic disorders, including hyperlipidaemia, hyperglycaemia, and hyperphenylalaninemia is reviewed.
Journal ArticleDOI
Oxidative stress in chronic renal failure.
Oliver Hasselwander,Ian S. Young +1 more
TL;DR: Current evidence suggesting that there is increased free radical production, antioxidant depletion and changes in lipoprotein composition in renal failure which will lead to oxidation of LDL and hence to accelerated development of atherosclerosis is summarized.
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Clinical and nutritional evaluation of phenylketonuric patients on tetrahydrobiopterin monotherapy
N. Lambruschini,Belén Pérez-Dueñas,Maria Antonia Vilaseca,A. Mas,Rafael Artuch,Rosa Gassió,Lilian Gómez,Alejandra Gutiérrez,Jaume Campistol +8 more
TL;DR: BH4 is a safe, and effective therapy in a selected group of mild, and moderate PKU patients who respond to the BH4 loading test, and low doses of BH 4 in monotherapy permit withdrawal of the special formula and guarantee a good clinical and nutritional outcome with no adverse side effects in PKU Patients.
Journal ArticleDOI
Oxidative stress induced by phenylketonuria in the rat: Prevention by melatonin, vitamin E, and vitamin C.
Francisco Martinez-Cruz,David Pozo,Carmen Osuna,A. Espinar,Concepcion Marchante,Juan M. Guerrero +5 more
TL;DR: It is concluded that PKU induces a clear state of oxidative stress that is somehow involved in the brain and body damage occurring in this inborn error and melatonin and other antioxidants are capable of preventing completely the damage induced by PKU.
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Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat.
Angélica Castaño,Antonio Ayala,José A. Rodríguez-Gómez,Antonio J. Herrera,Josefina Cano,Alberto Machado +5 more
TL;DR: The results suggest that the decrease of brain protection against oxidative damage could induce brain damage by disturbing the turnover rate of some monoamines.
References
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Journal ArticleDOI
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
TL;DR: Glutathione peroxidase activity is found to be associated with a relatively stable, nondialyzable, heat-labile, intracellular component which is separable from hemoglobin, by gel filtration and ammonium sulfate precipitation.
Journal ArticleDOI
Lipid peroxides and human diseases.
TL;DR: A method to determine the lipid peroxide level in human serum or plasma and its profile of change in several human diseases is described and Intervention of lipid peroxides in the pathogenesis of certain diseases is also mentioned.
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Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study.
TL;DR: A case-control study was conducted to investigate the association between serum selenium and risk of death from acute coronary heart disease (CHD) as well as risk of fetal and non-fetal myocardial infarction (MI) in an area with an exceptionally high mortality from cardiovascular diseases.
Journal Article
An approach to free radicals in medicine and biology
TL;DR: A classification of diseases in which radical generating processes may play a role is presented in the hope that it may aid in the understanding and treatment of these diseases.