Journal ArticleDOI
Self-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450.
Dominique Pessayre,Veronique Descatoire,Mitka Konstantinova-Mitcheva,Joao-Carlos Wandscheer,Barton Cobert,Regine Level,Jean-Pierre Benhamou,Maryse Jaouen,Daniel Mansuy +8 more
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TLDR
It is concluded that TAO induces its own transformation into a metabolite which forms a stable complex with the iron (II) of reduced cytochrome P-450.About:
This article is published in Biochemical Pharmacology.The article was published on 1981-03-15. It has received 99 citations till now. The article focuses on the topics: Tertiary amine.read more
Citations
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Journal ArticleDOI
In vitro and in vivo drug interactions involving human cyp3a
TL;DR: Cytochrome P4503A (CYP3A) is importantly involved in the metabolism of many chemically diverse drugs administered to humans and makes it a major contributor to presystemic elimination following oral drug administration.
Journal ArticleDOI
Pharmacokinetic Drug Interactions of Macrolides
TL;DR: These incriminated macrolide antibiotics should not be administered concomitantly with other drugs known to be affected metabolically by them, or at the very least, combined administration should be carried out only with careful patient monitoring.
Journal ArticleDOI
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
T Shimada,F P Guengerich +1 more
TL;DR: In vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen aflatoxin B1 to its genotoxic 2,3-epoxide derivative is cytochrome P-450NF, a previously characterized protein that also catalyzes the oxidation of nifedipine and other dihydropyridines, quinidine, macrolide antibiotics, various steroids, and other compounds.
Journal ArticleDOI
Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p
Steven A. Wrighton,Patrick Maurel,Erin G. Schuetz,Paul B. Watkins,Beverly Young,Philip S. Guzelian +5 more
TL;DR: It is concluded that, in addition to glucocorticoids, macrolide antibiotics are specific inducers of P-450p.
Book ChapterDOI
Inhibition of Cytochrome P450 Enzymes
TL;DR: Cytochrome P450s (P450s) are subject to inhibition/inactivation by various chemically diverse agents, which may interact directly or indirectly with either the P450 prosthetic heme or the protein moiety or with both moieties.
References
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Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
Inhibition of theophylline clearance by troleandomycin.
TL;DR: It is suggested that possibility of inducing theophylline toxicity, including seizures, as was observed in one of the patients in this study, may be at least a partial explanation for the apparent benefit of troleandomycin in chronic asthma.
Journal ArticleDOI
Troleandomycin: Effectiveness in steroid-dependent asthma and bronchitis☆☆☆
Sheldon L. Spector,Sheldon L. Spector,Fred H. Katz,Fred H. Katz,Richard S. Farr,Richard S. Farr +5 more
TL;DR: The steroid dose-reducing capacity of troleandomycin (Tao), a macrolide antibiotic, was substantiated by a double-blind crossover study of 74 corticosteroid-dependent asthmatic and bronchitic subjects and the antibiotic property of Tao did not explain improvement.
Journal ArticleDOI
Diethylaminoethyl 2,2-diphenylvalerate HCl (SKF 525-A)—In vivo and in vitro effects of metabolism by rat liver microsomes—Formation of an oxygenated complex
TL;DR: This new complex is believed to be responsible for the observed noncompetitive inhibition of drug metabolism in vitro by SKF 525-A.
Journal Article
SKF 525-A inhibition, induction, and 452-nm complex formation.
M K Buening,Michael R. Franklin +1 more
TL;DR: Induction with daily doses of SKF 525-A for several days increased total cytochrome P-450 content up to 5-fold, which was more than induction with phenobarbital, but this was evident only after destruction of the complex with ferricyanide.
Related Papers (5)
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more