Journal ArticleDOI
Senescence-accelerated-mouse (SAM) : a novel murine model of accelerated senescence
TLDR
The animal model for accelerated senescence named the Senescence-Accelerated Mouse (SAM) was developed in the laboratory (Department ofSenescence Biology, formerly Department of Pathology, Chest Disease Research Institute, Kyoto University) beginning in 1970.Abstract:
n animal model for accelerated senescence named the Senescence-Accelerated Mouse (SAM) was developed in our laboratory (Department of Senescence Biology, formerly Department of Pathology, Chest Disease Research Institute, Kyoto University) beginning in 1970. In this review, the circumstances related to development of SAM, characteristics of aging, pathologic phenotypes, and genetic background of this model are described.read more
Citations
More filters
Journal ArticleDOI
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,Hiroki Aizawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,Hitoshi Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Ryozo Nagai,Yo-ichi Nabeshima +16 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, including short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema as mentioned in this paper.
Journal ArticleDOI
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.
Susan A. Farr,Susan A. Farr,H. Fai Poon,Dilek Dogrukol-Ak,Jeniffer Drake,William A. Banks,Edward Eyerman,D. Allan Butterfield,John E. Morley +8 more
TL;DR: The hypothesis that oxidative stress can lead to cognitive dysfunction and provide evidence for a therapeutic role for antioxidants is supported and the hypothesis that antioxidant treatment can reverse cognitive dysfunction is supported.
Journal ArticleDOI
Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review
Joaquin J. Garcia,Laura López-Pingarrón,Priscilla Almeida-Souza,Alejandro Tres,Pilar Escudero,Francisco A. García-Gil,Dun Xian Tan,Russel J. Reiter,J. M. Ramirez,Milagros Bernal-Pérez +9 more
TL;DR: The present work reviews the current information related to the beneficial effects of melatonin in maintaining the fluidity of biological membranes against free radical attack, and discusses its implications for ageing and disease.
Journal ArticleDOI
Changes in the structural complexity of the aged brain
Dara L. Dickstein,Doron Kabaso,Anne B. Rocher,Jennifer I. Luebke,Susan L. Wearne,Patrick R. Hof +5 more
TL;DR: Findings suggest that age‐related neuronal dysfunction, which must underlie observed decline in cognitive function, probably involves a host of other subtle changes within the cortex that could include alterations in receptors, loss of dendrites, and spines and myelin dystrophy, as well as the alterations in synaptic transmission.
References
More filters
Journal ArticleDOI
On the Nature of the Function Expressive of the Law of Human Mortality, and on a New Mode of Determining the Value of Life Contingencies
TL;DR: The frequent opportunities I have had of receiving pleasure from your writings and conversation, have induced me to prefer offering to the Royal Society through your medium, this Paper on Life Contingencies, which forms part of a continuation of my original paper on the same subject, published among the valuable papers of the Society, as by passing through your hands it may receive the advantage of your judgment.
Journal Article
Development of a Strain of Spontaneously Hypertensive Rats
Kozo Okamoto,Kyuzo Aoki +1 more
TL;DR: The incidence of the spontaneous occurrence of hypertension increased, the development of hypertension occurred at younger ages from generation to generation, and all of the F3 to F6, rats developed spontaneous hypertension within 15 weeks of age.
Journal ArticleDOI
Development of a strain of spontaneously hypertensive rats.
Kozo Okamoto,Kyuzo Aoki +1 more
TL;DR: Okamoto-Aoki et al. as discussed by the authors found that the spontaneous occurrence of hypertension increased with age and the development of hypertension occurred at younger ages from generation to generation, increasing significantly above those of normotensive controls of the same age.
Journal ArticleDOI
The effect of retarded growth upon the length of life span and upon the ultimate body size
Journal ArticleDOI
Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.
TL;DR: Fluorescence intensity in the presence of a constant amount of amyloid fibrils reached a plateau with increase in the thioflavine T concentration, and the fluorescence was considerably diminished when structure of the amyloids fibril was disrupted by guanidine-HCl treatment.