Journal ArticleDOI
Sequence and secondary structure analysis of the 5'-terminal region of flavivirus genome RNA.
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TLDR
The prediction of a common structure among a number of different flaviviruses, despite the lack of extensive sequence homology, suggests that this secondary structure is functionally important.About:
This article is published in Virology.The article was published on 1988-02-01. It has received 202 citations till now. The article focuses on the topics: Flavivirus & Murray Valley encephalitis virus.read more
Citations
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Flaviviridae :T he Viruses and Their Replication
TL;DR: The present research attacked the Flavivirus infection through two mechanisms: Membrane Reorganization and the Compartmentalization and Assembly and Release of Particles from Flaviv virus-infected Cells and Host Resistance to Flaviviral Infection.
Book ChapterDOI
Molecular biology of flaviviruses.
TL;DR: An overview of the molecular biology of the flaviviruses is presented, which are enveloped positive-strand RNA viruses capable of causing a number of important human diseases.
Journal ArticleDOI
The dengue viruses.
E A Henchal,J R Putnak +1 more
TL;DR: Patients present with a severe febrile illness characterized by abnormalities of hemostasis and increased vascular permeability, which in some instances results in a hypovolemic shock.
Journal ArticleDOI
Dengue Virus Structural Differences That Correlate with Pathogenesis
Katrin C. Leitmeyer,David W. Vaughn,Douglas M. Watts,Rosalba Salas,Iris Villalobos,de Chacon,Celso Ramos,Rebeca Rico-Hesse +7 more
TL;DR: A method for comparing dengue type 2 genomes (reverse transcriptase PCR in six fragments) directly from patient plasma is developed to better reflect the true composition of viral RNA populations in the natural host and permit their association with pathogenesis.
Journal ArticleDOI
The Molecular Biology of West Nile Virus: A New Invader of the Western Hemisphere
TL;DR: A large body of data on the molecular biology of WNV and other flaviviruses has already been obtained, and aspects of virion structure, the viral replication cycle, viral protein function, genome structure, conserved viral elements, host factors, virus-host interactions, and vaccines are discussed in this review.
References
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Journal ArticleDOI
DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
Journal ArticleDOI
The use of thin acrylamide gels for DNA sequencing.
Frederick Sanger,Alan Coulson +1 more
TL;DR: Using the plus and minus [l] and the terminator [3] methods, serious variations in the distances between consecutive nucleotide bands in regions of dyad symmetry where base-paired loop structures can form are found, and this can lead to difficulties of interpretation.
Journal ArticleDOI
Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution
Charles M. Rice,Edith M. Lenches,Sean R. Eddy,Se Jung Shin,Rebecca L. Sheets,James H. Strauss +5 more
TL;DR: The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained and implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flaviv virus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.
Journal ArticleDOI
RNA secondary structures and their prediction
Michael Zuker,David Sankoff +1 more
TL;DR: This is a review of past and present attempts to predict the secondary structure of ribonucleic acids (RNAs) through mathematical and computer methods, especially the use of thermodynamic criteria to construct an optimal structure.
Journal ArticleDOI
Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus
Bernhard Dietzschold,William H. Wunner,Tadeusz J. Wiktor,A D Lopes,M. Lafon,C L Smith,Hilary Koprowski +6 more
TL;DR: It is concluded that arginine-333 is essential for the integrity of an antigenic determinant and for the ability of rabies viruses to produce lethal infection in adult mice.